Conversation
Replying to
This is the real deal !
It not only demonstrates that adenosine recovery by cells is inadequate, and gets metabolised to depletion, but purine signalling throughout the body AND the brain are going through issues. Adenosine and normal sleep are intertwined.
5
12
42
Replying to
Does this suggest that eating more protein could speed up recovery from a PEM state?
2
6
Replying to
There is likely to be an cell membrane adenosine salvage transporter system failure here. The loss of body adenosine means it has to be re-synthesised to novo, an energy dependent system. Without sufficient adenosine, then less available to make ATP. I’m not sure if ribose helps.
1
1
7
Replying to
If I search for this, I find papers that say trypanosomes salvage purines from their host. That might explain the reported similarity between sleeping sickness and this illness.

