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This is the real deal !
It not only demonstrates that adenosine recovery by cells is inadequate, and gets metabolised to depletion, but purine signalling throughout the body AND the brain are going through issues. Adenosine and normal sleep are intertwined.
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Does this suggest that eating more protein could speed up recovery from a PEM state?
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There is likely to be an cell membrane adenosine salvage transporter system failure here. The loss of body adenosine means it has to be re-synthesised to novo, an energy dependent system. Without sufficient adenosine, then less available to make ATP. I’m not sure if ribose helps.
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SLC29A1 mutation for ENT1 (adenosine reuptake transporter) present in 2/3 of my patients, the severer cases being homozygous for this anomaly. The SCL28A1 mutation was one of the top mutation separating cases from controls.
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Alcohol inhibits ENT1 and if there is a mutation in ENT1, it might explain alcohol intolerance in MECFS patients.
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Someone pointed out this diagram which shows ROS decreasing Hypoxathine degradation and adenosine recycling. I thought it might be of interest to you.
Source : nature.com/articles/pr198
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