We now have more details about the human CRISPR work. And I'm sorry, but He Jiankui is a criminal as far as I'm concerned:
blogs.sciencemag.org/pipeline/archi
Conversation
My understanding, from this slide, is that Lulu is a heterozygote with a 15bp (in frame!) deletion, and Nana is heteroallelic, with a 4 bp deletion in one allele, and a 1 bp deletion in the other. But yeah. I agree--criminal. drive.google.com/file/d/1A2PxZx
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This absolutely makes my stomach sink. And they're still going, apparently without institutional review? Is there any chance of this being stopped?
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Ick. I'd been assuming it was a publicity stunt to "raise awareness" (get 15 minutes of fame) and the actual genetic work hadn't really happened. This is so very much worse.
Jiankui He violated China's 2003 regulation:
cn-healthcare.com/article/201811
#crisprbabies #bioethics
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Just spent some time trying to find the consent forms, since He's website is down. Eventually found them on archive.org: web.archive.org/web/2018112806 , web.archive.org/web/2018112806 (supplement/followup consent). Reads half methods section, half contract.
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Pandora’s CRISPER box has been opened. It’s frightening but was perhaps inevitable.
This is like entering the atomic age of biotech, the first salvo has been launched.
Based on all that I've seen about it so far my initial impression is he should be in jail for what he did. Open to being convinced otherwise.
I agree and hope he is prosecuted if Chinese law believes the same. Horrible.