We found drug-treated mets often harbored private driver mutations whereas untreated mets did not. Polyclonal seeding was common in lymph node mets (n=19/35, 54%; mostly untreated) and untreated distant mets (n=20/70, 29%), but less frequent in treated mets (n=9/90, 10%). 2/4
-
-
Prikaži ovu nit
-
With a new computational method, we estimated that metastasis commonly occurred several years prior to diagnosis in breast (2.4 years, range 0-3.3), lung (3.6 years, range 2.8-3.7) and colorectal (4.1 years, range 3.1-4.6) cancers, in consistent with early metastatic seeding. 3/4
Prikaži ovu nit -
Further, these data suggest that the natural course of metastasis is selectively relaxed relative to early tumor development and that metastasis-private mutations are not drivers of cancer spread but are instead associated with drug resistance. 4/4
Prikaži ovu nit
Kraj razgovora
Novi razgovor -
Čini se da učitavanje traje već neko vrijeme.
Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.