John Connolly

@hotirishmonkey

CSO Tessa Therapeutics , Director Program in Translational Immunology IMCB A*Star, Adj Prof University; all views are my own.

Singapore
Vrijeme pridruživanja: rujan 2013.

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    Strong leadership behind an opportunity targeting core immune tolerance mechanisms.

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    Interleukin-23 engineering improves CAR T cell function in solid tumors

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    Highlights, insights, and commentary from Day 2 of Sitges - chasing the light on CAR T cell therapies: Is there going to be a shake-out in the cell therapy niche?

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    31. sij

    Great comment from Alex on the infamous HIV-2019nCoV paper that explains sequence analysis to a layperson… …and worth reading for the mic drop comment at the end alone

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    31. sij

    Combining infusions of cancer-killing T cells with an experimental could boost effectiveness of in , according to researchers.

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    Highlight: “I advise people to avoid it all together,” Loncar Investments Chief Executive Officer says about a coronavirus vaccine. “There’s two things that biotech companies… are always looking for: attention and cash.”

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    31. sij

    W Hazelton - NANOBODY BASED TRI-SPECIFIC CHIMERIC ANTIGEN RECEPTOR TO TREAT ACUTE MYELOID LEUKAEMIA CD33 x CD123 x CLL1 trispec CAR-T for AML in TanCAR format current construct found to be suboptimal on CLL1

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    30. sij

    Our latest expert interview focuses on ways to improve cell therapy performance through the lens of an experienced antibody developer - bioTwitter's own !

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  10. 30. sij

    Had a fantastic discussion with Sally Church around the science of VSTs. Thanks!

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  11. proslijedio/la je Tweet
    29. sij

    We decided to join the 2019-nCoV race for new medicines using our new discovery pipeline. Let's see if AI can make it cheaper, faster, and (add your keyword)... This is what we live for. Starting a short sprint now, so mark your calendars. Also, open for collaborations.

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    26. sij

    Wow!!! Check out this thread! Amazing job pulling this together! Thank you Dr. Muge Cevik

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    26. sij

    As researchers, we are typically removed from immediate responses to epidemics and instead tend focus on longer-term solutions to problems. But, did you ask yourself what experiment or analysis you could do today to help stop the spread of ? Do it!

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    According to the wiki page — which I am finding very fast & accurate, tell me if I'm wrong — the death toll is up to 57, all in China. 15 countries outside of mainland China have reported 45. cases. Canada and Turkey joined the list.

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    25. sij

    Reading about the quarantine of 15 cities in China (48M people) to stop the spread of is mind-boggling. Imagine imposing mandatory quarantine (no cars, buses, trains, flights in or out) in 15 cities across the US and how well that will go over🤔

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    25. sij

    In 2003 (SARS), 6.8 million passengers from China travelled on international flights. In 2018, 10X higher @ 63.7 million.

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    24. sij

    High dose intravenous Vitamin C in RAS mutant cancers (, ) New RAS dialog from Drs. Lew Cantley () and Jihye Yun cc:

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    Congratulations to Dr. Cliona Rooney, Thomas J. Rosenbalm Presidential Endowed Chair and head of CAGT's translational research labs, for being honored at this year's WISE luncheon honoring inspiring women in science

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    24. sij

    Met-Flow from & colleagues A novel flow cytometry-based method that captures the metabolic state of immune cells by targeting key proteins and rate-limiting enzymes across multiple pathways.

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    24. sij

    This is such an exciting area right now and great work from the JC team. High dimensional flow cytometry meets immunometabolics! It’s only just beginning:

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