But isn’t there a bias in RCTs that enroll younger, healthier, non-minority, way better psychosocial support....etc than patients seen in clinical practice. I think there are limitations to both & we need to know what type of data could be captured from both sources.
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Same as astronomy (the ultimate retrospective science) or theoretical physics. RWE studies are profoundly powerful, just need to understand limitations. Google, Waze, Uber etc in same camp. Waze best example
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Data means very little when examining
@raredisease due to small sample size. The patient is the expert in these cases and must be heard.@MLIWIThanks. Twitter will use this to make your timeline better. UndoUndo
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But also ignores that there are plenty of RCTs that are pragmatic and include a generalisable population. There is a bit difference between an efficacy and an effectiveness study and the population included. They can’t be lumped together to discredit the design.
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