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Our new
#P53 is in service! Pumper 53 is located in our Shedden Station and features a Hale 1500 gpm pump, 1000 gallons of water & a 30 gallon foam tank. We’re looking forward to it serving the#Southwold community for many years.pic.twitter.com/dkiN940ZGt
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Saturation mutagenesis, CRISPR-Cas9 mediated genome editing, ChIP-Seq and RNA-Seq show that hotspot
#p53 missense mutations exhibit loss-of-function and dominant-negative effects without gain-of-function@DanaFarber@broadinstitute@BroadCancerhttps://science.sciencemag.org/content/365/6453/599 … -
I folded a protein today. It was, unsurprisingly, very difficult without a chaperone. The protein is
#p53 and the structure is a subunit of 1TUP.#sciartpic.twitter.com/xwAwFL3Ig7Prikaži ovu nit -
Fresh online
#Review by Galit Lahav@harvardmed discussing the multiple mechanisms that regulate p53 activity and cell fate https://go.nature.com/2XBtRlz#p53#geneexpression#cellfatepic.twitter.com/N6kAdRT94z
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Breakdown of the
#p53 protein is responsible for over 50% of cancers. Now, a team from the Storr and@WarrenLabSFU at@SFUChemistry has designed a series of compounds to stabilize and re-activate this protein. https://bit.ly/2Gct97T pic.twitter.com/sV69yLdzci
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Check this new paper
@CD_AACR from@EvangeliaLoizou@sloan_kettering. They describe the mode of action for gain of function mutations for#p53 in#leukemia. Great work!#PhD#scientists4future#Cancerhttp://cancerdiscovery.aacrjournals.org/content/early/2019/05/08/2159-8290.CD-18-1391 … -
Fascinating article about the ways animals have evolved to avoid getting cancer
#p53#LIF#immunesurveillance@PNASNewshttps://www.pnas.org/content/116/6/1825 … -
Go to http://www.refine.bio search for a cancer and see how speedy it returns research results. Super fast. cc:
@CancerDataLab I tried searching for#neuroblastoma#medulloblastoma#p53#ALK#glioma -
Dear all, after 4 years of work my paper is out! It took a lot of hard work but also support from a lot of people that I couldn’t have done it without them!
#CD_AACR#AML#p53#WeillCornellMedicine#MSKCChttps://twitter.com/CD_AACR/status/1127988863081824259 …
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Interpretate p53 IHQ in endometrial carcinoma can be difficult, specially wild type vs absence. I found very useful this paper (https://bit.ly/2WDXq9a ). But I would like to know how you would report this case: WT or absence? Do you report low-wild type?
#gynpath#eec#p53 pic.twitter.com/FkrDmPxJ6i
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#ICYMI Dr. Cooper's Informational Webcast about Ziopharm's TCR-T Program. FDA Clearance of IND for Sleeping Beauty trial at NCI; Recent Exclusive License from NCI for library of T-cell receptors against neoantigens in hotspots#KRAS#p53#EGFR https://ir.ziopharm.com/events-presentations …pic.twitter.com/qRJwRrcdfK
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Opposite effect: Protein widely known to
#Fight#Tumors also Boosts#Cancer#Growth Researchers find evidence that genome 'guardian' can stimulate cancer:#p53 ... https://buff.ly/2UAZ0mI pic.twitter.com/V9FqDgYRVz
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Congratulations Moshe Oren of
@WeizmannScience, newly elected NAS foreign associate!#NASmember#NAS156#biochemistry#p53#CancerResearch http://www.nasonline.org/news-and-multimedia/news/2019-nas-election.html … -
Blunted mitochondrial adaptations post training; NEW by
@triatciccio@DrJonLittle@BlueSpotScience and others; for details: https://www.physiology.org/doi/abs/10.1152/ajpendo.00233.2019 …#enduranceexercise#HIIT#p53#exercise#skeletalmuscle#PGC1alphapic.twitter.com/SDvhRZWPgB
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The Mitochondrial Protein MAVS Stabilizes p53 to Suppress Tumorigenesis
#Mitochondrial#p53#Tumorigenesishttps://www.sciencedirect.com/science/article/pii/S2211124719317085?dgcid=rss_sd_all … -
Awesome case. Thnx. We looked at PCs in
#CLL in the marrow. They are + in ~10% of cases, associated with young age &#TP53 alterations. They are#MYC +#cyclinD1 +#p53 + by#IHC recommend mentioning them in the report if you see them. https://www.ncbi.nlm.nih.gov/m/pubmed/30086334/ …pic.twitter.com/GFozQRIeflOvo je potencijalno osjetljiv multimedijski sadržaj. Saznajte više
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What is Li-Fraumeni Syndrome? Watch link below published by
@DanaFarber#lifraumeni#lifraumenisyndrome#lifraumenisyndromeawareness#p53#ChildhoodCancer#breastcancer#sarcoma#coloncancer#braincancer#thyroidcancer#lungcancerhttps://www.lfsassociation.org/blog/2018/06/28/what-is-lfs-video/ … -
EU financed support to national and local authorities of
#Mongolia in terms of equipment for biosafety laboratories implemented by Mongolian partners and#P53 project of the EU CBRN Centre of Excellence#ISTC#Ulaanbaatar.pic.twitter.com/oexydi526Y
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P53 Binding In The
#Genome:
At 0-nt to 5-nt variant p53RE DNA elements
0-nt variant p53RE: TGCCCGGGCA
81,922 0-nt to 5-nt variant p53RE DNA elements
P53 regulates the cell cycle, functions as #tumor suppressor#p53
https://www.cell.com/iscience/fulltext/S2589-0042(19)30103-8?rss=yes …
https://www.nature.com/articles/onc2016443 …pic.twitter.com/4aJjF77fxQ
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