Rezultati pretraživanja
  1. Online now: Daratumumab monotherapy for patients with intermediate-risk or high-risk smoldering multiple myeloma: a randomized, open-label, multicenter, phase 2 study (CENTAURUS). ⁩ ⁦⁩ ⁦

  2. We just published our Phase I/II study of carfilzomib, bendamustine and dex in newly diagnosed myeloma with 100% ORR (89% VGPR, 63%CR). CD34 collection was not impaired. High ORR and cost-effective

  3. We don’t propose indefinite rev in the paper. However, what is the cost of treating a fracture or renal failure?

  4. New article: PHLPP Sensitizes Multiple Myeloma Cells to Bortezomib Through Regulating LAMP2.

  5. New article: Donor Lymphocyte Infusions After Allogeneic Transplantation: A Single-Center Experience.

  6. Read the conclusion. The trial used Len continuous like maintenance. Our conclusion was 2 years in the paper to match the Spanish group

  7. T4 Other approaches

  8. T3 DETER: studying MRD rates after 1 and 2 yr on treatment. Comparing flow and NGS

  9. T3 DETER trial-focusing on high risk SMM only. 2yr total treatment. 288 participants NCT03937635

  10. T3 EAA173: 1. does adding dara to L + D boost response rate,slow down progression? 2. Dex for 1 year -increase response?

  11. T2 E3A06 benefited high risk SMM. Low risk probably can continue on observation

  12. T2 E3A06 rx-len 25 mg days 1-21 indefinitely vs observation. At 3 yrs, PFS 91% in Len group, 66% in observation

  13. T2 E3A06 asked if you need dex at all. Used MRI to exclude pts with true MM; 244 pts in all

  14. T2 QUIRIDEX 119 pts PFS, Survival benefit for SMM rx up to 2 yr of len with dex HR 0.28 doi: 10.1016/S1470-2045(16)30124-3

  15. 20/20/20 or 20/2/30 means >20% PC in marrow, >2g/dl M spike, FLC ratio>20; if 2 or more, average 29 mo to MM progression

  16. more than 20% PC in marrow, >2g/dl M spike, Free light chain ratio >20

  17. T1 20/20/20 rule for high risk SMM likely to be new standard (Lakshman Blood Can J 2018 8:59)

  18. What's a SliM CRAB?

  19. T1 Spanish Def: 95% CD19-/dim CD 45-/dim CD38low CD 56high AND with immunoparesis and/or >2g/dl of IgA or 1g proteinuria

  20. Odgovor korisniku/ci

    What is proteinuria?

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