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NatureBiotech: Microbiome studies in rodents that have linked human diseases to microbiomes questioned: Derek Lowe commentary http://bit.ly/3b8nP2w on a recent Cell paper http://bit.ly/31plPyu tells us we need much more rigorous evidence
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CAR-T cells for solid tumors: there's a new target, Claudin-6. And combination with an RNA vaccine delivering Claudin-6 to immune cells boosts their function in mouse models of cancer http://bit.ly/2U2GM0b
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A human T cell receptor directs tumor cell killing via recognition of MR1 and cancer cell-derived metabolites https://go.nature.com/30ShljG
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Quantitative proteomic profiling of 375 cell lines from from Cancer Cell Line Encyclopedia http://bit.ly/2tMtaeX
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RT mike_schatz "RT NatureBiotech: ICYMI Clairvoyante, a multitask convolutional deep neural network for variant calling using single molecule sequencing mike_schatz
#NBThighlight https://go.nature.com/2Uf9kFi " -
RT NatureBiotech: Long-term clearance of HIV in a second patient after a bone-marrow transplant using donor cells lacking functional CCR5. https://go.nature.com/2TuyxKM
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Single insect sequenced: de novo mosquito genome from just 100ng of DNA using modified DNA prep PacBio
@PacBio http://bit.ly/2Gcmo63#NBThighlight https://www.mdpi.com/2073-4425/10/1/62 … -
Yeast introns are needed for starvation survival https://go.nature.com/2VXcvP8 & News and Views https://go.nature.com/2SWe3qA
#NBTHighlight https://go.nature.com/2VXcvP8 -
Correction of Huntington’s phenotype using compounds that target mutant huntingtin protein to autophagosomes. https://go.nature.com/2q6Oz0e
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Cell-surface proteomics in intact fly brains with peroxidase-mediated proximity biotinylation http://bit.ly/2tDYgpf
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Culture of cynomolgus monkey embryos for 20 days models early post-implantation development. http://bit.ly/2JE41rA http://bit.ly/2PCMKmk
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Two-photon microscope with 400 illumination enables imaging rates up to 1 kHz in awake mice https://go.nature.com/2Ps5Ag4
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Combining cultivation with metagenomics AKA culture-enabled metagenomics improves our understanding of sparse microbiomes in human cystic fibrosis sputum samples, and could prove broadly applicable
#NBTHighlight https://go.nature.com/3aHPXJs -
@NatureBiotech Why does the nucleus of a somatic cell require require an Oocyte to be enucleated but the nucleus of a spermatozoon does not require an Oocyte to be enucleated?#NBTHighlight@DrOlufunmilayo#SundayThoughts -
@NatureBiotech What happens in Somatic Cell Nuclear Transfer if the nucleus of a somatic cell is injected into an Oocyye that is not enucleated? Been curious!#SundayThoughts#SundayMotivation@DrOlufunmilayo#NBTHighlight
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