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New tools to expand the RNA editing are currently looked after by scientists. Would be a significant leap to alter genetic abnormalities without causing permanent damage to the genome.
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Besides ADARs being native to the cell, will elicit no immune response there is, however, a major drawback as it can make only a few kinds of change to the RNA. It can overwrite the function without breaking the RNA backbone.
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In treatment modality, RNA editing would be potentially less dangerous to immune reaction than are CRISPR-based approaches.
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"Some cancers hijack important cell-signalling pathways, such as those involved in cell death or proliferation. If RNA editors could be conscripted to turn off key signalling molecules temporarily, says Nina Papavasiliou from
@DKFZ “we could see the tumour die”#365DaysOfSciencePrikaži ovu nit -
RNA editing tools have mostly employed Enzymes called adenosine deaminases acting on RNA (ADARs) which upon binding to RNA alter their sequence from adenosine to inosine. APOBECs from cytidine deaminases family change cytosine into uracil.
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Cas9 used in gene editing could elicit immune responses/leads to permanent accidental changes to the genome. RNA editing makes short term changes to eliminate protein aberrations where damaging changes wouldn't be accumulated, transferred to progeny & discarded
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It, however, got overshadowed by the DNA-editing tool CRISPR–Cas9. Specifically being bombarded with a question like "Why do we need this when there’s DNA editing?"
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At the adipose tissue level insulin resistance is measured by ADIPO-IR (Adipose Insulin Resistance) using fasting insulin level with NEFA (non esterified fatty acid) also known as FFA (Free Fatty Acid)
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Whole body insulin resistance is measured by HOMAIR (Homeostatic Model Assesment for for Insulin Resistance) using fasting glucose level with fasting insulin level.
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There is no substitute to real Guru. The best of best is available in India. India now is not only the land of Ideas but the land of opportunities.
#365DaysOfScience And, rightly said sir, India
matters to me and I matter to India
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Prof. Mashelkar Made a transformational change in CSIR, considered as one of the ten most significant achievements of Indian Science and Technology in the 20th century by JV Narlikar. Added Innovation component to Research and Development;
centric Innovation
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His is a journey of how TATA trust supported a bright young boy in him, gave India one of the greatest Innovator & scientist. Being the director of NCL Pune transformed from reverse engineering to creation of Intellectual property among the best of the world
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He fondly remembers his mother and how she instilled cultural values in him that motivated him in the successful legal crusade against US patent on 'wound healing properties of turmeric'.
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SARS-GZ02 in which the S protein has evolved with the closest diversity too doesn't have sequence insertions as in 2019-nCoV. It is intriguing to know from where the virus to have acquired such unique insertions naturally that too in such a short span of time.
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They checked the alignment of the unique inserts against all viral genomes. Surprisingly, it aligned with HIV-1 proteins. Authors suggest this not to be fortuitous finding since all 4 inserts matched only with HIV1 structural proteins.
#365DaysOfScience#CoronavirusOutbreak pic.twitter.com/tdR0XWWvKq
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Phylogenetic tree suggests close resemblance of 2019-nCoV with SARS CoV as previously reported. They found 4 insertions in the gp of 2019-nCoV which are not present in other coronaviruses after multiple sequence alignment with all available coronaviruses.
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Today I am presenting a brief bio sketch of Prof. Har Gobind Khorana, a very well known name in India. Prof Khorana is credited with his discovery of Genetic codons; a triplet of nucleotides, which carry the genetic code of the cell to form proteins.
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Patients were randomized in 1:1 ratio to receive CDK4/6 inhibitors (n=52) or multiagent chemotherapy (n=54). Investigators analyzed changes in the low-risk-of-relapse (ROR) score between baseline and surgery in both categories.
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They for the first time show along with AR, REST; an AR cofactor, also have a repressive effect on the SPINK1 protein. Casein Kinase 1 shows antagonism over REST. High expression of REST was exhibited when the FDA approved anti CK1 drug was administered.
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In animal models and prostate cancer cell lines they have demonstrated an elevation in the levels of SPINK1 protein. It was also associated with an increase in the levels of neuroendocrine markers found in aggressive prostate cancer.
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