Magnificent illustration. HMS comes through again!
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I believe ACE refers to Angiotensin Converting Enzyme, which is responsible for converting Angiotensin l to Angiotensin II, which does a number of things including vasoconstriction of vessels
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Antibody-mediated neutralization would reduce the risk of cytokine storm from macrophages and allow opsonization to clear out the virus.
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Beautiful
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ACE-2 receptors are found in the alveolar epithelial cells within the lungs and are basically required for cellular entry of COVID-19. If we can block the receptor with an ACE-2 inhibitor could provide a targeted treatment. ACE-1 is also found in the epithelial cells of the lungs
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Why not give a trial to OX40 antagonist (GBR 830) to contain the cytokine storm? https://pubmed.ncbi.nlm.nih.gov/30738171/ https://drug-dev.com/glenmark-pharmaceuticals-novel-monoclonal-antibody-to-enter-phase-ii/ …
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