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hangingnoodles's profile
Jag Bhalla
Jag Bhalla
Jag Bhalla
Verified account
@hangingnoodles

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Jag BhallaVerified account

@hangingnoodles

Errors We Live By—@BigThink—Short Exoteric Essays…on bad ideas that run our lives—I’m Not Hanging Noodles on Your Ears—Sneaky Science Gift Book NatGeo…RT ≠ love

Washington DC
bit.ly/1BcafFZ
Joined May 2009

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    1. David Chapman‏ @Meaningness 10 Dec 2018

      An important practical problem plus an attractive technical formulation generate an exciting research discipline, with funding, journals, conferences, and the appearance of interesting incremental results. Usually this is all wasted because fundamental assumptions are false.

      3 replies 11 retweets 37 likes
      Show this thread
    2. David Chapman‏ @Meaningness 10 Dec 2018

      David Chapman Retweeted David Chapman

      The foundational asumptions of most research fields are forgotten as soon as possible, because they are inconveniently wrong. This is one major reason science has become so unproductive, I think. I’ve had to relearn this lesson repeatedly myself:https://twitter.com/Meaningness/status/1072210402094641152 …

      David Chapman added,

      David Chapman @Meaningness
      This is why I stopped working in the field after putting three years into it. Took me that long to realize it was a dead end.
      Show this thread
      2 replies 8 retweets 18 likes
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    3. David Chapman‏ @Meaningness 10 Dec 2018

      I spent three years working in structure-based drug discovery before I understood that its fundamental assumption, that intermolecular force fields derived from in vacuuo small-molecule measurements can predict large-molecule interactions in water, was utterly wrong.

      4 replies 4 retweets 26 likes
      Show this thread
    4. Joe Edelman  🕳‏ @edelwax 10 Dec 2018
      Replying to @Meaningness

      Same! But for me it was just about a year. 2003. Really threw myself at the water ligand van der waals thing

      1 reply 1 retweet 0 likes
      Jag Bhalla‏Verified account @hangingnoodles 10 Dec 2018
      Replying to @edelwax @Meaningness

      similar boat…did "drug design" in 90s…left & looked into it again 20 years later…little new science/ideas (just faster computers)

      12:18 PM - 10 Dec 2018
      1 reply 0 retweets 0 likes
        1. ꙮvchinnikov‏ @ovchinnikov 10 Dec 2018
          Replying to @hangingnoodles @edelwax @Meaningness

          How would you approach drug design now if starting from scratch and having adequate funding? (Asking for a friend).

          0 replies 0 retweets 0 likes
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