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thank you google, for this perfection https://twitter.com/monosynth/status/1224648976952987648 …pic.twitter.com/7MuiDqhcyG
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i found the source and am going to watch forthwithhttps://www.youtube.com/watch?v=bKPjFC7O6-U …
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anyway check out that erect mane! they're apparently not a truly pre-domesticated lineage, but it's been wild for pretty long timepic.twitter.com/a4Iez4ujQd
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you can see this on an env tree as well SARS is the outgroup to the RaTG13-like seqs, RaTG13 has a branch length of zero suggesting it's identical to the common ancestor of the clade w nCov and C45, and they branch off separately from the common ancestorpic.twitter.com/PnMDC3wbMZ
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your military env (CoVZC45), RaTG13, and nCov all v similar as expected, SARS significantly distant RaTG13 looks basal to both C45 and nCov (e.g. identical to the ancestral sequence) -C45 has picked up 2 mutations, nCov a single, different mutationpic.twitter.com/qgvIEV9YYu
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turns out it's highly conserved across coronaviruses, it's also 95% similar to SARS itself yes these two are most similar to each other, but it's a tiny protein, 5% difference for a 75 amino acid protein is just a couple of residues here, compared to SARSpic.twitter.com/VVvivP6OV0
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there was a groundhog day musical? w music by tim minchin??? didn't know he could do serious music tho i shouldn't be surprisedhttps://www.youtube.com/watch?v=gjqcTHQ0ijo …
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