Links for stuff I may've mentioned this weekend: - Chromosome selection: https://www.gwern.net/Embryo-selection#fn6 … - selection unlimited: https://www.gwern.net/Embryo-selection#limits-to-iterated-selection-the-paradox-of-polygenicity … - Catnip: https://www.gwern.net/Catnip - Advertising A/B test: http://www.gwern.net/Ads - Anti-spaced-repetition: https://www.gwern.net/Statistical-notes#program-for-non-spaced-repetition-review-of-past-written-materials-for-serendipity-rediscovery-archive-revisiter …
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It's just maddening coz you*could*give the final embryo something like 80% lower risk of alzh or heart disease and it would be just*a cheap edit massively worth it in $/QALYs. Obvs things like the George Church list far from current capacity and synthesis would render it obsolete
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but it's basically the opposite of the common media coverage. "CRISPR causes tons of unintended mutations" tons of headlines for n=3 mice that counted sibling differences as CRISPR mutations, took one year to retract despite key criticisms being made the next day
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There are more recent results showing other nasty off-target mutations, IIRC.
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that's just the most egregious example. Studies showing off-target mutations don't beat https://www.nature.com/articles/nature16526 … that showed one in ~3000 editions or https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007503 … that didn't find any. Other recent headline catching studies are stuff like upregulating p53 (if serious..
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only relevant for ex vivo theraphy with edited stem cells/T cells) or stuff like https://www.nature.com/articles/s41586-018-0380-z … https://www.nature.com/articles/nbt.4192 … that is on target. What I mean is that you get double-digit % efficiency in semi-suspicious Chinese embryo editing studies...
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or things like https://www.biorxiv.org/content/early/2018/09/01/393231 … giving <1% Efficiency can get higher than 66% or close to 100% or have this very low results, some of the is Cas9 vs. other proteins, sometimes it's sequence to edit, sometimes protein-binding to the DNA, etc. Might improve, might not
End of conversation
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