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gwern's profile
gwern
gwern
gwern
@gwern

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gwern

@gwern

Writer, independent researcher, Internet 𝘣𝘦𝘴𝘴𝘦𝘳𝘸𝘪𝘴𝘴𝘦𝘳

Present day. Present time. (Ahahaha!)
gwern.net
Joined November 2008

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    1. Custom Wetware‏ @Minthos_ Oct 16
      Replying to @gwern

      Save appearance? I'm just calling you out on your hypocrisy. You identified a dosage (guesstimated to around 8 ug or so) that had no measurable effect on you. You identified another dosage (150 ug or so) that had a strong effect on you.

      2 replies 0 retweets 0 likes
    2. Custom Wetware‏ @Minthos_ Oct 16
      Replying to @Minthos_ @gwern

      Somewhere in between is a dosage that will have mild effects on you. You didn't care to find out. Instead you bombastically claim that microdosing is bullshit and anyone who claims otherwise is tripping.

      1 reply 0 retweets 0 likes
    3. gwern‏ @gwern Oct 16
      Replying to @Minthos_

      I claim that the prior is minuscule, the existing evidence in favor of it is bullshit which no one wants to test & fully explained by standard biases, and the highest-quality datapoint so far strongly favors the null.

      1 reply 0 retweets 0 likes
    4. Custom Wetware‏ @Minthos_ Oct 16
      Replying to @gwern

      So in the absence of evidence you trust your bias. Excellent science.

      1 reply 0 retweets 0 likes
    5. gwern‏ @gwern Oct 16
      Replying to @Minthos_

      I disagree it's bias. We know from vast experience most chemicals do nothing, have reasonable dose-response curves, there are few to no 'microdoses' for other drugs, and so on. Extraordinary claims require extraordinary evidence.

      1 reply 0 retweets 0 likes
    6. Custom Wetware‏ @Minthos_ Oct 16
      Replying to @gwern

      It's not extraordinary to claim that a small dose of LSD has a small effect. What I want to know is how those effects differ in quantity and quality from the effects of a normal dose. You can't answer that.

      1 reply 0 retweets 0 likes
    7. gwern‏ @gwern Oct 16
      Replying to @Minthos_

      Indeed, it is not extraordinary. What is extraordinary is claiming that a small dose can have a large effect on daily functioning, that even smaller dose differences can make or break this effect, and that this effect is radically different than the effect of large doses...

      1 reply 0 retweets 0 likes
    8. Custom Wetware‏ @Minthos_ Oct 16
      Replying to @gwern

      LSD is pretty extraordinary. People have reported unexpected results and you have dismissed them without investigating. Of course some of the claims are bullshit. But are all of them bullshit? You have no basis for calling bullshit because you have no evidence.

      1 reply 0 retweets 0 likes
    9. gwern‏ @gwern Oct 16
      Replying to @Minthos_

      Lack of evidence for something extremely improbable is excellent reason to justify dismissing it. Ordinary claims require only ordinary evidence, and extraordinary claims require extraordinary evidence. LSD microdosing, if proponents are right, would be unprecedented.

      1 reply 0 retweets 0 likes
    10. Custom Wetware‏ @Minthos_ Oct 16
      Replying to @gwern

      I have seen a lot of anecdotes from people claiming some kind of effect. I too have experienced some kind of effect. That is indisputable. The only defensible position you can take is to question what the effects are. Instead you dismiss it as "there are no effects". Wtf?

      1 reply 0 retweets 0 likes
      gwern‏ @gwern Oct 16
      Replying to @Minthos_

      /rolls eyes Fine. 'There are no effects besides those driven by publication bias, selective recall of data (see recent LSD microdosing paper!), expectancy effects, overly large doses in the perceptual range, & other effects of no particular interest & not the claimed mechanism.'

      12:48 PM - 16 Oct 2018
      1 reply 0 retweets 0 likes
        1. Custom Wetware‏ @Minthos_ Oct 16
          Replying to @gwern

          Replace "There are no" with "There is no evidence for" and we have a deal.

          0 replies 0 retweets 0 likes
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