I think sometimes about the fact that Jeanne Calment has been the oldest human ever for almost my entire life, has held it for the past 17 years after dying 122yo, the closest runner up so far was still 3 years younger, and the current oldest human is only 115. (And she smoked.)
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Calment is just a weird weird weird outlier in GRG... Context here is thinking about embryo selection & life expectancy GWASes: https://www.biorxiv.org/content/early/2018/07/06/363036 … Looks like you could easily increase life expectancy by half a year using embryo selection and current PGSes? Not bad!
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Replying to @rajivpoc
Aside from the general 'compression of morbidity' observation (very hard to live longer by having worse health...), you can get some insight into what exactly it's doing by looking at the genetic correlations - lung cancer (smoking?) and heart disease are big ones.
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(That is, lung cancer and heart attacks cause huge reductions in QALYs even when they don't kill you - associated morbidity like strokes, dragging around oxygen tanks, etc. Preventing them extends both lifespan & healthspan. So since that's how the longevity PGS seems to work...)
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