N=2149. Given that the N needed for similar outcomes in other complex traits is >100X higher, this sounds fishy.
20 PCs might be overdoing it. In any case, they do claim replication - and what ancestry or population stratification could there possibly be so powerfully predictive of personality in both Finns and South Koreans? Those are not very similar populations.
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Section 7 & 8 from the supplement are a bit strange. It seems like they've only tried to replicate whether the same SNP sets emerge in the different populations, but they've estimated heritability independently in each w/o cross-validation
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And with the assumption that for each individual, each SNP has the 'average effect size' of its SNP sets, regardless of which SNP sets the individual has...
End of conversation
New conversation -
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Having read more carefully now, the reported variance explained is R^2 of polygenic risk scores estimated & applied within sample (no cross-validation, supplement p.34)
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