I hadn't thought too much of @drjohnm John Mandrola's piece on intravenous tPA for stroke, until I saw this Top People response.pic.twitter.com/s3HbDrGbWA
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obligatory infographic summarizing the evidence indexed at (grepmed search “tpa evidence summary”): https://www.grepmed.com/images/1330 - NINDS-II with a whopping 160 patients in each armpic.twitter.com/6n5Od3Janv
Reading them one by one. First- MAST. Used streptokinase ( not currently used). MRS improved by similar % that mortality worsened. Would at least some patients take this gamble. “I’d rather die that be disabled froma stroke”?
I just read this in full and it’s genuinely one of the most depressing things I’ve ever read
This is an amazing piece of work. And. Time to treatment argument is so damn fragile.pic.twitter.com/qON8FbQIwT
An outstanding piece of work for all physicians. Seriously, such a good review of lit / tx. Thanks .@First10EM
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