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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. Health Nerd‏Verified account @GidMK Jul 27

      We spent endless billions researching hydroxychloroquine, and knew by August 2020 that it didn't work, but ivermectin which has been given to 100s OF MILLIONS OF PEOPLE...still no answer. Shameful

      7 replies 9 retweets 140 likes
      Show this thread
    2. David Gorski, MD, PhD‏Verified account @gorskon Jul 27
      Replying to @GidMK

      I would argue that we actually *do* know, with approximately as much certainty as we had a year ago for #HydroxyChloroquine, that #Ivermectin almost certainly doesn’t work. Low prior probability + equivocal clinical trials = doesn’t work.

      9 replies 8 retweets 61 likes
    3. Health Nerd‏Verified account @GidMK Jul 27
      Replying to @gorskon

      Sure, but we could've easily had a large trial really testing the idea by now. If we'd rolled it into RECOVERY or SOLIDARITY, it might've prevented (or caused) literally millions of people to get the drug

      2 replies 1 retweet 10 likes
    4. Health Nerd‏Verified account @GidMK Jul 27
      Replying to @GidMK @gorskon

      We're still arguing about awful, low-quality evidence, but as a global research community that is a choice. We could definitely have tested this properly by now, and we really dropped the ball

      1 reply 1 retweet 6 likes
    5. Nicholas Bauer, PhD  👨‍🔬 🔬‏ @BioTurboNick Jul 27
      Replying to @GidMK @gorskon

      At some point isn't it unethical to try something you don't think will work just to shut people up?

      5 replies 0 retweets 12 likes
    6. Jan Merta‏ @lunruj Jul 28
      Replying to @BioTurboNick @GidMK @gorskon

      That is my issue as well. But it is tricky. Ivermectin has a good safety in a reasonable treatment regime, this makes the testing less problematic. Plus there are some studies, mostly pretty poor but I guess it may be seen as giving it some plausibility.

      1 reply 0 retweets 0 likes
    7. David Gorski, MD, PhD‏Verified account @gorskon Jul 28
      Replying to @lunruj @BioTurboNick @GidMK

      Here's what made me rate the prior plausibility of #ivermectin as a treatment for #COVID19 to be very low. The in vitro experiments that showed antiviral activity used concentrations several times what is achievable in the blood with normal dosing. That's a huge red flag.

      1 reply 11 retweets 34 likes
    8. David Gorski, MD, PhD‏Verified account @gorskon Jul 28
      Replying to @gorskon @lunruj and

      That's why I keep saying about #ivermectin: Low prior plausibility/probability + equivocal clinical trials = almost certainly doesn't work.

      1 reply 0 retweets 4 likes
    9. David Gorski, MD, PhD‏Verified account @gorskon Jul 28
      Replying to @gorskon @lunruj and

      Let's crank it up to an extreme example to show you what I mean. Homeopathy has in essence, no prior plausibility from basic science; yet there are quite a few equivocal trials of homeopathy that seem to show a benefit, even meta-analyses that claim to find a benefit.

      1 reply 0 retweets 3 likes
    10. David Gorski, MD, PhD‏Verified account @gorskon Jul 28
      Replying to @gorskon @lunruj and

      Do these equivocal clinical trials overcome the low prior plausibility of homeopathy? Of course not. No, I'm not saying the prior plausibility of #ivermectin is homeopathy-level, but the same principle applies, just to a less extreme extent.

      2 replies 0 retweets 1 like
      David Gorski, MD, PhD‏Verified account @gorskon Jul 28
      Replying to @gorskon @lunruj and

      Yes, it's possible that #ivermectin might have a therapeutic benefit vs. #COVID19, but, again, its low prior plausibility plus equivocal and low quality clinical trials *strongly* suggest that it probably does not.

      5:22 AM - 28 Jul 2021
      • 1 Like
      • Antechinus The Oberserver
      1 reply 0 retweets 1 like
        1. David Gorski, MD, PhD‏Verified account @gorskon Jul 28
          Replying to @gorskon @lunruj and

          My prediction for #ivermectin is thus the same as it was for #HydroxyChloroquine a year ago. It's highly unlikely that it works against #COVID19. However, if a therapeutic effect is seen in large randomized trials, it will almost certainly be weak, far less than a "miracle cure."

          0 replies 3 retweets 6 likes
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