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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. Nick Hiebert‏ @The_Nutrivore Jul 20
      Replying to @waseemkiani @NutritionMadeS3 and

      Trial duration. You need >5 years for enough power for ACM. 4S: 5.4 yrs IDEAL: 4.8 yrs CARDS: 3.9 yrs ASPEN: 4 yrs JUPITER: 1.9 yrs IMPROVE-IT: 6 yrs FOURIER: 2.2 yrs The reason IMPROVE-IT doesn't see the effect is because subjects already achieved good LDL targets at baseline.

      1 reply 1 retweet 4 likes
    2. Matthew Madore‏ @MattMadore576 Jul 20
      Replying to @The_Nutrivore @waseemkiani and

      This figure from the Cooper Longitudinal Study really demonstrates the importance of duration with respect to all-cause mortality, considering any change should be driven by a reduction in CVD deaths. https://pubmed.ncbi.nlm.nih.gov/30571575/ pic.twitter.com/fhhi0Mj0TK

      2 replies 0 retweets 4 likes
    3. Nick Hiebert‏ @The_Nutrivore Jul 20
      Replying to @MattMadore576 @waseemkiani and

      Are you aware of any data like this specifically looking at ACM?

      1 reply 0 retweets 0 likes
    4. Matthew Madore‏ @MattMadore576 Jul 20
      Replying to @The_Nutrivore @waseemkiani and

      4S has a Kaplan-Meier curve for ACM, but I can't think of one stratified by achieved LDL like this off the top of my head.

      1 reply 0 retweets 1 like
    5. Nick Hiebert‏ @The_Nutrivore Jul 20
      Replying to @MattMadore576 @waseemkiani and

      That would be sick.

      1 reply 0 retweets 0 likes
    6. Matthew Madore‏ @MattMadore576 Jul 20
      Replying to @The_Nutrivore @waseemkiani and

      Theirs looks like this with a reduction from ~184 mg/dL mean LDL to ~120 mg/dLpic.twitter.com/hk3YSoylO4

      1 reply 1 retweet 2 likes
    7. Nick Hiebert‏ @The_Nutrivore Jul 20
      Replying to @MattMadore576 @waseemkiani and

      I should plug this isn't to RevMan and see where the differences become significant.

      2 replies 0 retweets 0 likes
    8. Matthew Madore‏ @MattMadore576 Jul 20
      Replying to @The_Nutrivore @waseemkiani and

      Another one for ACM from long-term WOSCOPS follow-up. The achieved reduction in the intervention during the initial trial (~5 years) was from ~190 mg/dL to ~140 mg/dL, statin use was only recorded for the first 10 years. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.115.018791 …pic.twitter.com/sC4zsFfyvy

      1 reply 0 retweets 2 likes
    9. Nick Hiebert‏ @The_Nutrivore Jul 20
      Replying to @MattMadore576 @waseemkiani and

      pic.twitter.com/bfrR0FhyWt

      1 reply 0 retweets 3 likes
    10. Matthew Madore‏ @MattMadore576 Jul 20
      Replying to @The_Nutrivore @waseemkiani and

      Perfectly exemplifies how the magnitude in reduction of LDL can alter the duration needed to see an effect

      2 replies 0 retweets 2 likes
      David Gorski, MD, PhD‏Verified account @gorskon Jul 20
      Replying to @MattMadore576 @The_Nutrivore and

      I think I need to mute this thread, as the notifications are getting out of hand.

      11:31 AM - 20 Jul 2021
      0 replies 0 retweets 0 likes

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