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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. Andrew Rothstein‏ @ASRothstein Mar 1
      Replying to @noorchashm @doritmi and

      Goal post moving alert: while I am just a lawyer, I had a concentration in bioethics and health law. Please provide detailed examples of data that acip and cdc are ignoring to create reassurance that would be sufficient to support your claims of negligence. No RFK jr.

      1 reply 1 retweet 27 likes
    2. Hooman Noorchashm MD, PhD‏ @noorchashm Mar 2
      Replying to @ASRothstein @doritmi and

      The vaccination of persons with occult or recent infection would exacerbate COVID-19 disease or cause thromboembolic event. Neither of which will be classified as "vaccine related". The following may get you closer to understanding my point.https://www.bmj.com/content/370/bmj.m3720 …

      9 replies 0 retweets 0 likes
    3. Jonathan Howard‏ @JHowardBrainMD Mar 2
      Replying to @noorchashm @ASRothstein and

      Again I still wonder why a small piece of mRNA in a vaccine would be more dangerous than the entire mRNA if previously infected people were re-exposed to covid? This is all theoretical since neither seems to cause a problem for the previously infected.

      1 reply 1 retweet 8 likes
    4. Hooman Noorchashm MD, PhD‏ @noorchashm Mar 2
      Replying to @JHowardBrainMD @ASRothstein and

      Persistent viral antigens will be dispersed within the tissues of the naturally infected. The idea is that upon reactivation of the antigen specific T-cells by the vaccine, these antigen-bearing tissues will be targeted leading to recurrent inflammatory state - deadly to some.

      2 replies 0 retweets 0 likes
    5. Jonathan Howard‏ @JHowardBrainMD Mar 2
      Replying to @noorchashm @ASRothstein and

      My question remains. Why would the vaccine be more dangerous than a second exposure to the actual virus?

      1 reply 1 retweet 5 likes
    6. Hooman Noorchashm MD, PhD‏ @noorchashm Mar 2
      Replying to @JHowardBrainMD @ASRothstein and

      Second exposure to a natural virus in an immune person is innocuous bc the person is usually immune. So the virus is neutralized and never takes hold. The vaccine forces the immune response because antigens are delivered in immunogenicity form via injection along w adjuvant.

      1 reply 0 retweets 0 likes
    7. R Marcucio‏ @mcfunny Mar 2
      Replying to @noorchashm @JHowardBrainMD and

      the mRNA vaccines do not contain an adjuvant

      1 reply 0 retweets 4 likes
    8. Hooman Noorchashm MD, PhD‏ @noorchashm Mar 2
      Replying to @mcfunny @JHowardBrainMD and

      mRNA is a self-adjuvant...actually.

      2 replies 0 retweets 0 likes
    9. Jonathan Howard‏ @JHowardBrainMD Mar 3
      Replying to @noorchashm @mcfunny and

      The virus contains mRNA. You are positing that the mRNA in the vaccine is dangerous but the mRNA in the virus is harmless. This makes so sense to me.

      1 reply 1 retweet 4 likes
    10. R Marcucio‏ @mcfunny Mar 3
      Replying to @JHowardBrainMD @noorchashm and

      I thought that the mRNA in the vaccine was made with modified bases to reduce immunogenicity.

      1 reply 1 retweet 3 likes
      David Gorski, MD, PhD‏Verified account @gorskon Mar 3
      Replying to @mcfunny @JHowardBrainMD and

      It is. The modified bases not only stabilize the mRNA but also decrease its immunogenicity.

      7:28 AM - 3 Mar 2021
      • 1 Retweet
      • 4 Likes
      • A Dad who enjoys nerdy things Ed MD (((Dorit Reiss))) MamaDeb ✡ דבורה פייגע
      2 replies 1 retweet 4 likes
        1. New conversation
        2. Hooman Noorchashm MD, PhD‏ @noorchashm Mar 3
          Replying to @gorskon @mcfunny and

          Negative. The mRNA vaccine is quite specifically immunogenic. Because of its mechanism of action. It is likely to be one of the most, if not the most, powerful and effective vaccine we've ever made. That does not make it intrinsically safer for every human being. Think Dave!

          3 replies 0 retweets 1 like
        3. (((Dorit Reiss)))‏Verified account @doritmi Mar 3
          Replying to @noorchashm @gorskon and

          Nothing is completely safe for every human being. In this case, we already know these vaccines have higher rates of anaphylaxis than routine vaccines, though still low. That’s not the debate.

          0 replies 0 retweets 1 like
        4. End of conversation
        1. New conversation
        2. Ed MD‏ @notdred Mar 3
          Replying to @gorskon @mcfunny and

          I have Dr. Hooman blocked, but for the sake of everybody else in this thread, the LNPs probably play the important adjuvanting role in these vaccines, and "empty" LNPs without mRNA added are quite immunogenic on their own

          1 reply 1 retweet 3 likes
        3. R Marcucio‏ @mcfunny Mar 3
          Replying to @notdred @gorskon and

          thank you for pointing that out!

          0 replies 0 retweets 1 like
        4. End of conversation

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