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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. Hooman Noorchashm MD, PhD‏ @noorchashm Feb 8
      Replying to @ENirenberg @gorskon and

      Read Ed. Read the fundamentals worked out by Michael Oldstone's work. U seem like a smart kid. Don't jump on band wagons. Read.

      2 replies 0 retweets 0 likes
    2. Hooman Noorchashm MD, PhD‏ @noorchashm Feb 8
      Replying to @noorchashm @ENirenberg and

      Seriously, I would spend some time reading Oldstone's work and follow-up. I think U will find it interesting.

      1 reply 0 retweets 0 likes
    3. Edward Nirenberg‏ @ENirenberg Feb 8
      Replying to @noorchashm @gorskon and

      No one disputed you on the principles of cellular immunity. The issue has been the fact that SARS-CoV-2 does not demonstrate endothelial cell tropism where such concerns would be relevant.

      1 reply 0 retweets 3 likes
    4. Hooman Noorchashm MD, PhD‏ @noorchashm Feb 8
      Replying to @ENirenberg @gorskon and

      Ed, can U please tell me Ur thoughts about how and why a large number of COVID-19 patient develop thromboembolic disease? U may know that anti-coagulation is now a SOC in the management of these patients. Also, U are aware that vasculitis is a pathological hallmark of the dz?

      1 reply 0 retweets 0 likes
    5. Edward Nirenberg‏ @ENirenberg Feb 8
      Replying to @noorchashm @gorskon and

      Vasculitis represents a rare manifestation of the clinical spectrum and vasculitis does not require direct infection of the vasculature. https://academic.oup.com/rheumatology/article/48/5/475/1786981 … There is considerable crosstalk between inflammation and thrombosis: https://www.tandfonline.com/doi/pdf/10.1080/09537104.2020.1817360?needAccess=true …https://www.nature.com/articles/nri3345 …

      2 replies 1 retweet 3 likes
    6. Edward Nirenberg‏ @ENirenberg Feb 8
      Replying to @ENirenberg @noorchashm and

      With respect to COVID-19 specifically: https://thorax.bmj.com/content/thoraxjnl/early/2021/01/06/thoraxjnl-2020-216243.full.pdf … Multiple concurrent mechanisms exist, none of which require endothelial infection.pic.twitter.com/FySU3Hzv6h

      2 replies 0 retweets 3 likes
    7. Hooman Noorchashm MD, PhD‏ @noorchashm Feb 8
      Replying to @ENirenberg @gorskon and

      Do me a favor and review this PubMed search....SARS-CoV-2 causes vascular injury leading to thromboembolic dz:https://pubmed.ncbi.nlm.nih.gov/?term=COVID-19+thromboembolic+disease …

      1 reply 0 retweets 0 likes
    8. Edward Nirenberg‏ @ENirenberg Feb 8
      Replying to @noorchashm @gorskon and

      That isn't the subject in dispute.

      1 reply 0 retweets 2 likes
    9. Hooman Noorchashm MD, PhD‏ @noorchashm Feb 8
      Replying to @ENirenberg @gorskon and

      Right. The subject in dispute is that any and all tissues (including blood vessels) harboring viral antigens can B expected to be targeted by the vaccine immune response. I would expect young people to tolerate this far more readily than the elderly and frail with CV disease.

      2 replies 0 retweets 0 likes
    10. Edward Nirenberg‏ @ENirenberg Feb 8
      Replying to @noorchashm @gorskon and

      Then we would see a drastic spike in thromboembolic events and deaths far beyond the background rate if this were true and yet this isn't observed.

      2 replies 0 retweets 3 likes
      David Gorski, MD, PhD‏Verified account @gorskon Feb 8
      Replying to @ENirenberg @noorchashm and

      Exactly. Dr. N's hypothesis would predict a major spike in deaths and thromboembolic events after nearly 30 million doses of vaccines. Quite simply, we haven't seen that.

      5:58 PM - 8 Feb 2021
      • 6 Likes
      • (((Wendy Orent))) Adrian Egli David Ridley Balgor Edward Nirenberg the sailing science shill ⛵️
      2 replies 0 retweets 6 likes
        1. New conversation
        2. Edward Nirenberg‏ @ENirenberg Feb 8
          Replying to @gorskon @noorchashm and

          I'd also add that the method of surveillance is etiologically agnostic. It defines a risk interval following vaccines and counts events and compares them to a background rate. It requires no assumptions about the vaccine or mechanism.

          1 reply 0 retweets 3 likes
        3. Hooman Noorchashm MD, PhD‏ @noorchashm Feb 8
          Replying to @ENirenberg @gorskon and

          Don't be convinced too easily. Ask @US_FDA @DrWoodcockFDA @pfizer @CDCDirector for the analytics. It's a signal that needs to be looked for - I suspect it'll be easiest to decipher in the elderly and frail with CV disease.

          1 reply 0 retweets 0 likes
        4. Show replies
        1. New conversation
        2. Hooman Noorchashm MD, PhD‏ @noorchashm Feb 8
          Replying to @gorskon @ENirenberg and

          We haven't looked David. And every post-vaccine death due to stroke or MI or PE has been ruled "unrelated" to the vaccine. Do U C yet? @DrWoodcockFDA @US_FDA @CDCDirector @pfizer need to look at all post-vaccine thromboembolism cases as potentially vaccine related.

          1 reply 0 retweets 0 likes
        3. Edward Nirenberg‏ @ENirenberg Feb 8
          Replying to @noorchashm @gorskon and

          It has been examined. Read the ACIP meeting notes from January 27, 2021. I linked the presentation to you.

          0 replies 0 retweets 1 like
        4. End of conversation

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