There's a really dangerous misinformed claim going around relating to COVID-19 vaccines. A while ago there was a trendy idea that part of the hypercoagulability from COVID-19 was because of endothelialitis caused by direct infection of endothelial cells by SARS-2.
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The major paper advancing this claim is here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext … It purports to demonstrate viral inclusions within endothelial cells consistent with SARS-CoV-2 infection, and notes ACE2 expression on the endothelial cells. Except...
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there are huge problems here. For one thing the citation for the claim that endothelial cells express ACE2 is this paper: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.104.510461 … There is no such claim in the paper. It's examining ACE2 expression within rat ventricles, which aren't endothelial tissue.
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The arguably even bigger issue here is that questions have been raised about whether the purported viral inclusions noted in this study even represent SARS-CoV-2 virions (rather they are perhaps more consistent with ER vesicles and associated ribosomes):https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31188-0/fulltext#back-bib1 …
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This is not the only paper to make comments about failures interpreting electron micrographs with respect to COVID-19: https://jasn.asnjournals.org/content/31/9/2223#ref-2 … The virions may easily be confused for clathrin-coated vesicles.
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Further, this paper notes that infection of human primary endothelial cells by SARS-CoV-2 did not occur until they were induced to express ACE2, which was not detected within them by profiling RNA or protein:https://mbio.asm.org/content/11/6/e03185-20 …
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Basically, it doesn't look too great for this hypothesis. That brings us to the vaccine claim. One individual has argued that it would be dangerous for individuals who had previously recovered from COVID-19 to receive these vaccines due to purported viral endothelialitis.
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Replying to @ENirenberg
Yes, and this individual is behaving very much like a crank. (Just check out my addendum.) Dude complained to my department chair to try to shut me up and doesn’t care that RFK Jr. republished his message as antivax propaganda.https://respectfulinsolence.com/2021/01/29/noorchashm-spreading-fear-of-covid-19-vaccines-on-an-antivax-website/ …
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Indeed. He’s tagging everyone under the sun from the FDA and various media outlets, trying to get attention. Against my better judgment (which says to ignore him), I finally broke down and just told him point blank that no one cares about his Twitter beef with me.

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