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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. Edward Nirenberg‏ @ENirenberg Feb 1

      There's a really dangerous misinformed claim going around relating to COVID-19 vaccines. A while ago there was a trendy idea that part of the hypercoagulability from COVID-19 was because of endothelialitis caused by direct infection of endothelial cells by SARS-2.

      5 replies 18 retweets 61 likes
      Show this thread
    2. Edward Nirenberg‏ @ENirenberg Feb 1

      The major paper advancing this claim is here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30937-5/fulltext … It purports to demonstrate viral inclusions within endothelial cells consistent with SARS-CoV-2 infection, and notes ACE2 expression on the endothelial cells. Except...

      1 reply 6 retweets 11 likes
      Show this thread
    3. Edward Nirenberg‏ @ENirenberg Feb 1

      there are huge problems here. For one thing the citation for the claim that endothelial cells express ACE2 is this paper: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.104.510461 … There is no such claim in the paper. It's examining ACE2 expression within rat ventricles, which aren't endothelial tissue.

      1 reply 5 retweets 17 likes
      Show this thread
    4. Edward Nirenberg‏ @ENirenberg Feb 1

      The arguably even bigger issue here is that questions have been raised about whether the purported viral inclusions noted in this study even represent SARS-CoV-2 virions (rather they are perhaps more consistent with ER vesicles and associated ribosomes):https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31188-0/fulltext#back-bib1 …

      1 reply 5 retweets 12 likes
      Show this thread
    5. Edward Nirenberg‏ @ENirenberg Feb 1

      This is not the only paper to make comments about failures interpreting electron micrographs with respect to COVID-19: https://jasn.asnjournals.org/content/31/9/2223#ref-2 … The virions may easily be confused for clathrin-coated vesicles.

      1 reply 5 retweets 14 likes
      Show this thread
    6. Edward Nirenberg‏ @ENirenberg Feb 1

      Further, this paper notes that infection of human primary endothelial cells by SARS-CoV-2 did not occur until they were induced to express ACE2, which was not detected within them by profiling RNA or protein:https://mbio.asm.org/content/11/6/e03185-20 …

      1 reply 6 retweets 12 likes
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    7. Edward Nirenberg‏ @ENirenberg Feb 1

      Basically, it doesn't look too great for this hypothesis. That brings us to the vaccine claim. One individual has argued that it would be dangerous for individuals who had previously recovered from COVID-19 to receive these vaccines due to purported viral endothelialitis.

      2 replies 6 retweets 17 likes
      Show this thread
    8. David Gorski, MD, PhD‏Verified account @gorskon Feb 1
      Replying to @ENirenberg

      Yes, and this individual is behaving very much like a crank. (Just check out my addendum.) Dude complained to my department chair to try to shut me up and doesn’t care that RFK Jr. republished his message as antivax propaganda.https://respectfulinsolence.com/2021/01/29/noorchashm-spreading-fear-of-covid-19-vaccines-on-an-antivax-website/ …

      2 replies 3 retweets 6 likes
    9. Edward Nirenberg‏ @ENirenberg Feb 1
      Replying to @gorskon

      That’s really unacceptable

      1 reply 1 retweet 4 likes
      David Gorski, MD, PhD‏Verified account @gorskon Feb 1
      Replying to @ENirenberg

      Yes. I told him that the only other people who have tried to silence me by complaining to my bosses about a blog post have been antivaxxers and cancer quacks. Not a good look. He’s heading into crank territory.

      9:46 PM - 1 Feb 2021
      • 5 Likes
      • Adrian Egli Nina Milanov the sailing science shill ⛵️ JMac n Cheese 🏳️‍🌈 (((Dorit Reiss)))
      1 reply 0 retweets 5 likes
        1. New conversation
        2. Edward Nirenberg‏ @ENirenberg Feb 1
          Replying to @gorskon

          The whole sequence of events is disquieting. Letting RFK Jr use your words to undermine confidence in a vaccine you purport to support? That's either an unprecedented level of naivete or you're lying about your support

          1 reply 1 retweet 4 likes
        3. David Gorski, MD, PhD‏Verified account @gorskon Feb 1
          Replying to @ENirenberg

          I think that he just has this idée fixe that he’s become obsessed with, so much so that he just can’t accept what a bad thing it is for antivaxxers to have co-opted his message and can’t back down when criticized for it. He’s just too convinced of his own righteousness.

          1 reply 1 retweet 5 likes
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