See what I mean about #Ivermectin being the new #Hydroxychloroquine? He's making EXACTLY the same argument HCQ cultists made February through June. How did that work out? Maybe #Ivermectin will work out better, but HCQ showed the danger of bypassing RCTs, even in a pandemic.https://twitter.com/badlandj/status/1336306106474373122 …
IKR? At least #Hydroxychloroquine had a semi-plausible mechanism of action, mild immunosuppression plus in vitro evidence of suppression of viral binding (although that latter observation never panned out in vivo).
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Like for Hydroxychloroquine, immunomodulatory effect is the key. Cytokine reduction of IVM was shown in vivo on hamsters, and was coupled with a better clinical presntations of treated hamsters. https://www.biorxiv.org/content/10.1101/2020.11.21.392639v1 …pic.twitter.com/TL4qJZHgUT
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