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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. David Gorski, MD, PhD‏Verified account @gorskon 30 Nov 2020

      Antivaxxers claim that #RNA in #Moderna and #Pfizer #COVID19 #vaccines will “permanently alter your DNA” or even “make you transhuman.” Such claims rest on utter ignorance of the totality of molecular biology. Same as it ever was from antivaxxers.https://sciencebasedmedicine.org/rna-vaccines-against-covid-19-will-not-permanently-alter-your-dna/ …

      22 replies 92 retweets 300 likes
    2. P.Y. Mund's Genealogy‏ @PYMundGenealogy 30 Nov 2020
      Replying to @gorskon

      Thank you. One question: Not a meaningful risk, but isn't there a non-zero chance of *any* RNA fragment being reverse transcribed, then integrated? Weren't many pseudogenes formed that way? (I mean, it would most likely be transcriptionally silent, but still non-zero.)

      1 reply 0 retweets 0 likes
    3. K-State Turk‏ @KStateTurk 30 Nov 2020
      Replying to @PYMundGenealogy @gorskon

      Since the human genome doesn’t code for reverse transcriptase and integrase, I’d put this possibility at 0%.

      1 reply 1 retweet 5 likes
    4. P.Y. Mund's Genealogy‏ @PYMundGenealogy 30 Nov 2020
      Replying to @KStateTurk @gorskon

      Somewhat higher than absolute 0%, though, as mRNA-derived pseudogenes exist. (I dimly remember endogenous retroviruses being a factor?)

      2 replies 0 retweets 1 like
    5. K-State Turk‏ @KStateTurk 30 Nov 2020
      Replying to @PYMundGenealogy @gorskon

      If this were true then we’d routinely observe non-retro viral gene integration into our genome all the time. I don’t believe this has ever been observed. Also the integrated retroviruses in our genome aren’t active or complete.

      1 reply 0 retweets 3 likes
    6. P.Y. Mund's Genealogy‏ @PYMundGenealogy 30 Nov 2020
      Replying to @KStateTurk @gorskon

      Well, there's a wide range between 'all the time' and 'not ever', and while safety-wise it's surely irrelevant, I imagine it's a micro-notch before 'not ever'. (There's nothing special about engineered mRNA's to spare them from what ever process integrates them, however rarely.)

      2 replies 0 retweets 0 likes
    7. K-State Turk‏ @KStateTurk 30 Nov 2020
      Replying to @PYMundGenealogy @gorskon

      Since virus infection occurs in humans and animals all the time, we would have surely observed non retroviral genes being integrated in the genomes of humans or animals by now. We haven’t. possibility remains 0%.

      1 reply 0 retweets 2 likes
      David Gorski, MD, PhD‏Verified account @gorskon 30 Nov 2020
      Replying to @KStateTurk @PYMundGenealogy

      Yep. I'd say that the chance of this happening is roughly on par with the chance that a 30C homeopathic remedy has a single molecule of original remedy in it—not zero, but so close to zero as to be functionally indistinguishable from zero.

      5:47 AM - 30 Nov 2020
      • 6 Likes
      • John Greer Tenebra99 Sue LC Matthew Roberts the sailing science shill ⛵️ P.Y. Mund's Genealogy
      1 reply 0 retweets 6 likes
        1. P.Y. Mund's Genealogy‏ @PYMundGenealogy 30 Nov 2020
          Replying to @gorskon @KStateTurk

          So relevant only on geological time scales, then, which thankfully isn't the recommended booster schedule for any vaccine...

          0 replies 0 retweets 0 likes
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