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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. keithlaw‏Verified account @keithlaw 24 Oct 2020
      Replying to @leeloyd1 @gorskon and

      You have an inaccurate understanding of what aerosols are, and how the virus leaves your respiratory tract. This is a common source of confusion for the layperson. Here's a good explanation of why you're mistaken.https://www.fast.ai/2020/06/26/particle-sizes/ …

      1 reply 1 retweet 7 likes
    2. Lee Loyd‏ @leeloyd1 24 Oct 2020
      Replying to @keithlaw @gorskon and

      I’m well versed in aerosols (<5-10microns)- also that larger droplets (>10 microns) rarely make it below the level of the glottis- thus infection below that level from larger particles is unlikely- Commonly misunderstood by the lay-person

      1 reply 0 retweets 0 likes
    3. Jerry Alexandratos  🇺🇸‏ @JNAlexandratos 24 Oct 2020
      Replying to @leeloyd1 @keithlaw and

      Covid-19 infection can start in the upper nasal tract (see news article below). That's why one of the symptoms can be loss of sense of taste and smell. As for you, see "Dunning-Kruger effect".https://www.news-medical.net/news/20201021/Study-shows-SARS-CoV-2-uses-a-receptor-to-efficiently-infect-human-cells.aspx …

      1 reply 0 retweets 2 likes
    4. Lee Loyd‏ @leeloyd1 24 Oct 2020
      Replying to @JNAlexandratos @keithlaw and

      Severe C19 is a lower respiratory tract infection- it preferentially replicates in the lower airways, needing to penetrate there directly to cause significant disease. It can bind to ACE2 receptors in a variety of other cells. Know the diff

      2 replies 0 retweets 0 likes
    5. Jerry Alexandratos  🇺🇸‏ @JNAlexandratos 25 Oct 2020
      Replying to @leeloyd1 @keithlaw and

      Covid-19 infection can start in the upper tract and spread lower. (Why do you think we're stupid?) As for needing to penetrate "directly" to cause "significant disease", <citation needed> very badly. That sounds impossible to determine in humans, so I think you're making it up.

      1 reply 1 retweet 4 likes
    6. Lee Loyd‏ @leeloyd1 25 Oct 2020
      Replying to @JNAlexandratos @keithlaw and

      ‘Both of these aspects indicate that this is an airborne agent that has to penetrate directly into the LRT to preferentially replicate there before causing disease.’https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-3707-y …

      1 reply 0 retweets 0 likes
    7. Jerry Alexandratos  🇺🇸‏ @JNAlexandratos 25 Oct 2020
      Replying to @leeloyd1 @keithlaw and

      Did you think I wouldn't or couldn't read article? That specific line is talking about SARS & MERS, not SARS-CoV-2. It's based upon inference, not experiment. Finally, that article was written in 2019 before SARS-CoV-2 was even discovered. SARS-CoV-2 properties are different.

      1 reply 1 retweet 3 likes
    8. Lee Loyd‏ @leeloyd1 25 Oct 2020
      Replying to @JNAlexandratos @keithlaw and

      So let me get this straight- you use an analogy about a bacterial infection to make your point, but take issue with me making a point using a past CORONAVIRUS that is similar in structure, function, and spread?!?! Classic coronabro!

      1 reply 0 retweets 0 likes
    9. Jerry Alexandratos  🇺🇸‏ @JNAlexandratos 25 Oct 2020
      Replying to @leeloyd1 @keithlaw and

      My analogy was about asymptomatic spread in general, not about Covid-19 in particular, explaining how you were misunderstanding the math. However, you were trying to say how SARS-CoV-2 infects specific cells using a related virus. That's not an analogy. It's an extrapolation.

      1 reply 1 retweet 3 likes
    10. Jerry Alexandratos  🇺🇸‏ @JNAlexandratos 25 Oct 2020
      Replying to @JNAlexandratos @leeloyd1 and

      I study infectious viruses at the molecular level for a living. When I say "citation needed", I mean it. When it comes to viral protein interactions, I can understand the articles because I write them, edit them, and on occasion review them. You haven't backed up your statements.

      2 replies 2 retweets 9 likes
      David Gorski, MD, PhD‏Verified account @gorskon 25 Oct 2020
      Replying to @JNAlexandratos @leeloyd1 and

      Next, he'll accuse you of beating him over the head with your qualifications and the amount of time you've been at this.😂

      8:10 AM - 25 Oct 2020
      • 4 Likes
      • the sailing science shill ⛵️ Nick Gorton, MD 🏳️‍🌈🐾 keithlaw Jerry Alexandratos 🇺🇸
      1 reply 0 retweets 4 likes

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