This is irresponsible.
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HOWEVER, that doesn’t mean that, when RCTs are either impractical or unethical (e.g., an RCT of vaccinated vs. unvaccinated children, which would leave the control group vulnerable to vaccine-preventable disease), we can’t still make strong conclusions from other study designs.
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Or NAC as an antidote to acetaminophen. No RCTs to support that. But before we used NAC OD of 180mg/kg was uniformly fatal w/o liver transplant. Now you can eat a Costco bottle of APAP, but if you get NAC in 4 hrs it's universal survival. Try getting an RCT past an IRB for NAC.
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