HCQ is not a vaccine. When Fauci used that terminology he was referring to its prophylactic use which was originally identified in SARS.
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Replying to @PaulVCooper1 @angela_bower and
Preinfection chloroquine treatment renders Vero E6 cells refractory to SARS-CoV infection https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69 … Antiviral effects here https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(03)00806-5/fulltext#.X1-kUuExGYA.twitter … Meta-analysis of RCTs https://www.medrxiv.org/content/10.1101/2020.09.30.20204693v1 …pic.twitter.com/y3ufAlURrU
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Replying to @3GHtweets @PaulVCooper1 and
You do realize the risks and benefits of any exposure is determined by epidemiological studies, not in-vitro studies, right?
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Replying to @crabb_vicki @PaulVCooper1 and
That is incorrect. Epidemiology is useful but the gold standard in therapeutics is either a RCT or meta-analysis, both considered level one evidence, which is why I included this paper:https://www.medrxiv.org/content/10.1101/2020.09.30.20204693v1 …
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Replying to @3GHtweets @PaulVCooper1 and
You do realize RCTs are epidemiological studies, right? A meta-analysis isn’t a “gold standard”. It’s a study of studies. It provides a pooled effect estimate. It has limitations too.
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Replying to @gorskon @crabb_vicki and
Also, it uses pooled outcomes, which almost always means that the authors couldn't massage the data to come up with a statistically significant result for any really important outcome, such as death or hospitalization. First read, it looks like a crap study to me.
1 reply 0 retweets 2 likes
Particularly suspicious, looking at the paper quickly (I'll have to read it in more detail later), I don't see any reports of whether the meta-analysis showed statistically significant results for any of the single outcomes used to make the composite outcome. I'd bet it didn't.
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