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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. David Gorski, MD, PhD‏Verified account @gorskon 23 Aug 2020

      David Gorski, MD, PhD Retweeted Dr. Stephen M. Hahn

      Commissioner, you have failed the American people. There are no randomized controlled clinical trial data supporting this EUA. You caved to political pressure from @realDonaldTrump. You have proven yourself unworthy to be @FDACommissioner. Resign.https://twitter.com/SteveFDA/status/1297642147945025536 …

      David Gorski, MD, PhD added,

      Dr. Stephen M. HahnVerified account @SteveFDA
      I am committed to releasing safe and potentially helpful treatments for #COVID19 as quickly as possible in order to save lives. We’re encouraged by the early promising data that we’ve seen about convalescent plasma. https://www.fda.gov/news-events/press-announcements/fda-issues-emergency-use-authorization-convalescent-plasma-potential-promising-covid-19-treatment … https://twitter.com/US_FDA/status/1297641809510899712 …
      Show this thread
      4 replies 56 retweets 163 likes
      Show this thread
    2. David Gorski, MD, PhD‏Verified account @gorskon 23 Aug 2020

      David Gorski, MD, PhD Retweeted Dr. Stephen M. Hahn

      This is utter nonsense. By making convalescent plasma available so widely, you’ve almost certainly guaranteed that these clinical trials will never accrue enough patients to answer the question of whether antibody therapy works against #COVID19.https://twitter.com/SteveFDA/status/1297642151199809537 …

      David Gorski, MD, PhD added,

      Dr. Stephen M. HahnVerified account @SteveFDA
      At the same time, we will continue to work with researchers to move forward with randomized clinical trials to study the safety and effectiveness of convalescent plasma in treating patients infected with the novel coronavirus.
      Show this thread
      5 replies 24 retweets 67 likes
      Show this thread
    3. Robert Amour‏ @kunstderfuge1 23 Aug 2020
      Replying to @gorskon

      Can I ask, it looks like this 35% number came from this statement: "Those who received transfusions within three days of diagnosis had a seven-day death rate of 8.7%, while patients who got plasma after four or more days had a mortality rate of 11.9%."

      1 reply 0 retweets 0 likes
    4. Robert Amour‏ @kunstderfuge1 23 Aug 2020
      Replying to @kunstderfuge1 @gorskon

      Dr. Hahn said that if "100 people are sick with COVID-19, 35 would be saved". Isn't it more accurately something like "if 100 people who died after being treated with plasma after 4 or more days had instead been treated within 3 days, 35 wouldn't have died."?

      2 replies 0 retweets 0 likes
    5. David Gorski, MD, PhD‏Verified account @gorskon 23 Aug 2020
      Replying to @kunstderfuge1

      He said that? What utter BS! Going from 11.9% to 8.7% mortality is a 3.2% absolute benefit. If this study is correct (and it's not a randomized controlled study, making it relatively unlikely to be correct), that means that with treatment you're 3.2%, not 35%, less likely to die.

      1 reply 0 retweets 1 like
    6. David Gorski, MD, PhD‏Verified account @gorskon 23 Aug 2020
      Replying to @gorskon @kunstderfuge1

      I would look at this the way we look at survival in oncology trials. Untreated patients had an 88.1% survival, while treated patients had a 91.3% survival. Sounds a lot less impressive that way, doesn't it? And it should, because it isn't impressive.

      1 reply 0 retweets 0 likes
    7. David Gorski, MD, PhD‏Verified account @gorskon 23 Aug 2020
      Replying to @gorskon @kunstderfuge1

      The 3.1% survival benefit is so small that I really don't believe it in a retrospective, uncontrolled study.

      1 reply 0 retweets 0 likes
    8. David Gorski, MD, PhD‏Verified account @gorskon 23 Aug 2020
      Replying to @gorskon @kunstderfuge1

      Also, using relative survival benefit numbers rather than absolute numbers is always a red flag for me. If you quote a number for a relative survival benefit, you really do have to quote the absolute survival benefit too, to put it in perspective.

      1 reply 0 retweets 1 like
      David Gorski, MD, PhD‏Verified account @gorskon 23 Aug 2020
      Replying to @gorskon @kunstderfuge1

      Think of it this way and use @SteveFDA's number of 35%, as incorrect as it is. A decrease in mortality by a treatment of 35% means a much different thing when mortality of the untreated patient is 10% than when untreated mortality is 50%.

      6:09 PM - 23 Aug 2020
      • 1 Like
      • dawn
      1 reply 0 retweets 1 like
        1. David Gorski, MD, PhD‏Verified account @gorskon 23 Aug 2020
          Replying to @gorskon @kunstderfuge1 @SteveFDA

          If untreated mortality is 10%, then a 35% decrease in mortality is 3.5% on an absolute basis. For a 50% untreated mortality, it's a 17.5% absolute decline.

          0 replies 0 retweets 1 like
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