Skipping Phase 3 of clinical trials and rushing out a COVID-19 vaccine is a *terrible* idea. It goes against medical ethics, puts people at greater risk and undermines trust in the vaccine approval system. It causes more problems than it tries to solve. Let me explain. 1/10
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Replying to @ZoeMcLaren
I did NOT advocate for skipping Phase 3. That is absolutely inaccurate. I said in my full thread to expand Phase 3 access to people in epidemic hotspots who wants to volunteer with 50/50% randomization. Do not misquote or misinterpret what I said. Also tag
@StevenSalzberg118 replies 23 retweets 212 likes -
Replying to @DrEricDing @ZoeMcLaren
I didn't advocate for skipping phase 3 either - not at all. But Twitter doesn't allow for subtlety
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Quoting you: "We don't have to wait months for phase 3 trials of
#COVID19 vaccines to finish. We have safe vaccines already, and millions of people (including me) would take them now if permitted. Just do it." If you aren't advocating skipping phase 3, please hone your messaging1 reply 0 retweets 20 likes -
Replying to @prf5 @StevenSalzberg1 and
Yep. As a writer, when people misconstrue what I meant, the first thing I do is to look at what I wrote and ask if it was a failure on my part to communicate well what I meant. Steve sure came across as advocating bypassing phase 3.
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It’s bad form for a writer to blame first his readers for misunderstanding him, rather than asking first if he screwed up communicating what he meant.
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Replying to @gorskon @StevenSalzberg1 and
My guess is that
@StevenSalzberg1 wrote a hasty tweet and was constrained by 280 characters. He didn't blame readers. However, the tweet was based on his essay published today in Forbes. I don't see any room for doubt about what he is advocating.https://www.forbes.com/sites/stevensalzberg/2020/08/02/start-vaccinating-now/#147f7229cf6e …1 reply 0 retweets 1 like -
Replying to @prf5 @StevenSalzberg1 and
I read it. It’s basically
#RightToTry for a#COVID19 vaccine and, as any clinical trialist knows, would basically make completing the necessary Phase 3 trial impossible. The real world practical effect would be to bypass phase 3 trials.2 replies 4 retweets 16 likes -
Replying to @gorskon @StevenSalzberg1 and
I can anticipate his response to what you are saying, but it would be better if we heard directly from him.
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I haven’t even gotten into how phase 1 and 2 trials are grossly inadequate for judging whether it’s safe to give a drug or vaccine to millions of people.
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Replying to @gorskon @StevenSalzberg1 and
@ZoeMcLaren's thread discusses, among other things, the inadequencies of phase 1 and 2 trials, and argues that phase 3 trials are requisite.0 replies 0 retweets 0 likesThanks. Twitter will use this to make your timeline better. UndoUndo
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