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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. Kevin K. Chung, MD‏Verified account @chungk1031 2 May 2020

      Kevin K. Chung, MD Retweeted Mark Hoofnagle

      I just saw this thread by @MarkHoofnagle and feel compelled to respond to clarify some things. Disclaimers: I am not an ID expert. I am a Medical Intensivist in the Military. These are not the official views of the DoD. Just my personal opinions. No financial COIs. 1/https://twitter.com/MarkHoofnagle/status/1256242036015063042 …

      Kevin K. Chung, MD added,

      Mark Hoofnagle @MarkHoofnagle
      I am truly sorry to say, Remdesivir is probably worthless, and we are seeing some fascinating drug company shenanigans, a thread.
      Show this thread
      15 replies 144 retweets 299 likes
      Show this thread
    2. Kevin K. Chung, MD‏Verified account @chungk1031 2 May 2020

      I have participated only as a site-AI but I have participated in investigator meetings since the inception of this trial so I have *some* inside knowledge. 2/

      1 reply 0 retweets 16 likes
      Show this thread
    3. Kevin K. Chung, MD‏Verified account @chungk1031 2 May 2020

      First off, this trial was conceived and protocol approved before our very first US case back in February. It is funded by NIAID. Not Gilead. Remdesivir was chosen because of its potential. Not financially motivated. Full info here. 👇 https://clinicaltrials.gov/ct2/show/NCT04280705 …

      2 replies 3 retweets 50 likes
      Show this thread
    4. Kevin K. Chung, MD‏Verified account @chungk1031 2 May 2020

      The early findings released this week were *preliminary*. Only 400 of the over 1000 subjects have complete data to analyze. This was an interim analysis by the DSMB to help inform the next trial. Results like these are typically not released. But these are not normal times...

      3 replies 1 retweet 33 likes
      Show this thread
    5. Kevin K. Chung, MD‏Verified account @chungk1031 2 May 2020

      Kevin K. Chung, MD Retweeted Kevin K. Chung, MD

      Info about what was released...https://twitter.com/chungk1031/status/1255548565184811008?s=20 …

      Kevin K. Chung, MD added,

      Kevin K. Chung, MDVerified account @chungk1031
      Preliminary results: Remdesivir had a 31% faster time to recovery than those who received placebo (p<0.001). https://www.niaid.nih.gov/news-events/nih-clinical-trial-shows-remdesivir-accelerates-recovery-advanced-covid-19 …
      Show this thread
      1 reply 2 retweets 19 likes
      Show this thread
    6. Kevin K. Chung, MD‏Verified account @chungk1031 2 May 2020

      Yes the Primary endpoint was changed. However, mortality was always a SECONDARY endpoint. The original primary endpoint was a complicated 8 point ordinal scale. It was merely simplified. History of changes here. 👇 https://clinicaltrials.gov/ct2/history/NCT04280705?V_15=View#StudyPageTop …

      2 replies 2 retweets 43 likes
      Show this thread
    7. Andrew Hersh‏ @andrewmhersh 2 May 2020
      Replying to @chungk1031

      Changing your primary ep just to “simplify” doesn’t really pass muster. If I walk in my sons room and he stops suddenly and stares at my guiltily-he did something wrong. Him telling me “nothing dad” doesn’t really change that fact

      2 replies 0 retweets 2 likes
      David Gorski, MD, PhD‏Verified account @gorskon 2 May 2020
      Replying to @andrewmhersh @chungk1031

      Yep. My skeptical antennae ALWAYS start twitching wildly when I see outcome switching in a trial. It’s a HUGE red flag.

      4:16 PM - 2 May 2020
      • 2 Likes
      • Kevin K. Chung, MD Dr Simon Ashworth
      1 reply 0 retweets 2 likes

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