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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    2. Ralph Weichselbaum‏ @rweichselbaum 28 Apr 2020
      Replying to @MohammadKhanMD

      This is trial as described is Ill advised I hope I am wrong. What does the consent look like no data and if you survive you can get cancer ?

      7 replies 3 retweets 78 likes
    3. Brandon Dyer‏ @BrandonADyer 28 Apr 2020
      Replying to @rweichselbaum @MohammadKhanMD

      Would love to hear the statistical justification for 5 patient enrollment and how you will *try* and figure out if the intervention did anything. With great potential for confounding factors and a single arm intervention I am shocked this made it through an IRB.

      1 reply 3 retweets 8 likes
      David Gorski, MD, PhD‏Verified account @gorskon 29 Apr 2020
      Replying to @BrandonADyer @rweichselbaum @MohammadKhanMD

      As am I. Are fear of #COVID-19 and desperation for any treatment leading IRBs to throw human research protections by the wayside, as long as it’s a COVID study? And how on earth are they going to see an efficacy signal in just five patients?🙄

      3:46 AM - 29 Apr 2020
      • 1 Retweet
      • 3 Likes
      • Quidama Fibroid New Research Nataniel Lester-Coll, MD
      1 reply 1 retweet 3 likes
        1. New conversation
        2. Nataniel Lester-Coll, MD‏Verified account @DrLesterColl 29 Apr 2020
          Replying to @gorskon @BrandonADyer and

          Well it is phase I so presumably primary endpoint is safety/feasibility, but agree with n=5 would be impossible to conclude anything meaningful. Which raises the question of whether risk to subjects/staff is justified. Hopefully there is more to this story.

          1 reply 0 retweets 1 like
        3. David Gorski, MD, PhD‏Verified account @gorskon 29 Apr 2020
          Replying to @DrLesterColl @BrandonADyer and

          True, but they claim it's a phase I/II trial, which means they're at least going to try to see a signal of efficacy.

          0 replies 1 retweet 2 likes
        4. End of conversation

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