So the “you’re rooting for the virus” sort of idiots who come out of the woodwork when I criticize the promotion of unproven #Hydroxychloroquine for #COVID19 also exist for economics. Lovely. 
https://twitter.com/StevenSkelton1/status/1247522652786319364 …
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Or we would’ve at least seen hints of such activity. We didn’t.
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Modest in certain situations, like helping to prevent people with severe illness from getting cathed. That's my uninformed guess, based on the anecdotal reports, willing (hoping, even) to be proved wrong by the data.
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They excluded severely ill patients from the study!! So, people who were going to get better got better a little faster? And it doesn't look like they adjusted for date of infection or any other important parameter. This is a crap study.
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We need to stop thinking it’s an antiviral and focus on its anti-inflammatory properties. If it’s got efficacy, it will be less like its antimalarial self and more like its anti-RA self. If this is true we need to note that early (prophylactic) administration will worsen outcomes
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Study showing premature inhibition if the inflammasome leads to worse outcomes during influenza infection (in mice) https://www.nature.com/articles/srep27912 …
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Yup, or it may even turn out to be harmful. Or there may be a window during which it's helpful. We just don't know right now. But patients have a right to know the alternatives, risks, and benefits, regardless of the political views of the person prescribing it...
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We just don't know is LIGHT YEARS from the over-the-top claims Trump has made. It's irresponsible. On the level of drinking bleach for autism irresponsible.
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And for more,
@UCSF's@annieluet speaks a few minutes on two slides, including trciky issue of getting dosage right to see if there is anything useful at all. She goes over 4 studies. https://twitter.com/JohnMashey/status/1246126115841658882 … e7-8
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Read the published literature. That modest, at best. Not better than that modest. Seriously, the horse is dead. Stop flogging it.
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