Skip to content
  • Home Home Home, current page.
  • Moments Moments Moments, current page.

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @
  • Language: English
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English UK
    • Español
    • Filipino
    • Français
    • Hrvatski
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Ελληνικά
    • Български език
    • Русский
    • Српски
    • Українська мова
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Have an account? Log in
    Have an account?
    · Forgot password?

    New to Twitter?
    Sign up
gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
Verified account
@gorskon

Tweets

David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

Tweets

  • © 2021 Twitter
  • About
  • Help Center
  • Terms
  • Privacy policy
  • Cookies
  • Ads info
Dismiss
Previous
Next

Go to a person's profile

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @

Promote this Tweet

Block

  • Tweet with a location

    You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more

    Your lists

    Create a new list


    Under 100 characters, optional

    Privacy

    Copy link to Tweet

    Embed this Tweet

    Embed this Video

    Add this Tweet to your website by copying the code below. Learn more

    Add this video to your website by copying the code below. Learn more

    Hmm, there was a problem reaching the server.

    By embedding Twitter content in your website or app, you are agreeing to the Twitter Developer Agreement and Developer Policy.

    Preview

    Why you're seeing this ad

    Log in to Twitter

    · Forgot password?
    Don't have an account? Sign up »

    Sign up for Twitter

    Not on Twitter? Sign up, tune into the things you care about, and get updates as they happen.

    Sign up
    Have an account? Log in »

    Two-way (sending and receiving) short codes:

    Country Code For customers of
    United States 40404 (any)
    Canada 21212 (any)
    United Kingdom 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Ireland 51210 Vodafone, O2
    India 53000 Bharti Airtel, Videocon, Reliance
    Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italy 4880804 Wind
    3424486444 Vodafone
    » See SMS short codes for other countries

    Confirmation

     

    Welcome home!

    This timeline is where you’ll spend most of your time, getting instant updates about what matters to you.

    Tweets not working for you?

    Hover over the profile pic and click the Following button to unfollow any account.

    Say a lot with a little

    When you see a Tweet you love, tap the heart — it lets the person who wrote it know you shared the love.

    Spread the word

    The fastest way to share someone else’s Tweet with your followers is with a Retweet. Tap the icon to send it instantly.

    Join the conversation

    Add your thoughts about any Tweet with a Reply. Find a topic you’re passionate about, and jump right in.

    Learn the latest

    Get instant insight into what people are talking about now.

    Get more of what you love

    Follow more accounts to get instant updates about topics you care about.

    Find what's happening

    See the latest conversations about any topic instantly.

    Never miss a Moment

    Catch up instantly on the best stories happening as they unfold.

    1. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      Main results (outcomes part 1): Body temperature recovery time: (a) Treatment group: 2.2 (SD 0.4) days (b) Control group: 3.2 (SD 1.3) days /9

      2 replies 5 retweets 23 likes
      Show this thread
    2. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      Main results (outcomes part 2): (a) Treatment group: 2 patients worsened (incl. 0 to severe), 19 stable, 25 improved. (b) Control group: 9 patients worsened (incl. 4 to severe), 5 stable, 17 improved. /10pic.twitter.com/WA3rXHO2qs

      7 replies 5 retweets 34 likes
      Show this thread
    3. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      The authors conclude that in spite of the small sample size, their study "partially confirms" the efficacy of hydroxychloroquine in the treatment of COVID-19. They add that, in the absence of a better alternative, it is a "promising practice" to use hydroxychloroquine. /11pic.twitter.com/C3paIZYy0S

      1 reply 12 retweets 46 likes
      Show this thread
    4. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      Convinced? I'm not, and here is why. ⚠️ /12

      2 replies 8 retweets 81 likes
      Show this thread
    5. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      Clear deviation from the protocol: The trial protocol on ChiCTR mentioned 3 groups, with 100 patients in each: (1) HCQ 400mg/d, (2) HCQ 200mg/d, and (3) a placebo. Where the heck is group 2, and why has placebo been replaced by standard care? http://www.chictr.org.cn/showprojen.aspx?proj=48880 … /13pic.twitter.com/W30VBBKubP

      13 replies 14 retweets 133 likes
      Show this thread
    6. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      Underpowered study: This trial was supposed to recruit 300 patients (200 receiving HCQ and 100 receiving placebo). Yet, the analysis reported in the preprint only includes 31 patients in the HCQ arm and 31 in the standard care arm. Of course, no explanation whatsoever... /14

      3 replies 6 retweets 112 likes
      Show this thread
    7. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      How big should it be? Assuming no loss to follow-up (which seems to be the case here), 5% type-1 error rate, 85% power and Fleiss CC, a total of 128 COVID-19 patients (64+64) would be required to demonstrate the 55% vs. 81% proportion of patients who "improved" in Table 2. /15

      1 reply 5 retweets 51 likes
      Show this thread
    8. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      Lucas Morin Retweeted Darren Dahly, PhD

      A multitude of underpowered studies will not be of any use if we want to seriously answer the question "Is hydroxychloroquine beneficial for patients with COVID-19?". 👇 https://twitter.com/statsepi/status/1234576310703398912?s=20 … /16

      Lucas Morin added,

      Darren Dahly, PhD @statsepi
      You enter a pitch black room to look for a small, specific object. You have a flashlight. As soon as you enter, the batteries die and the once bright light fades. You struggle in the dark to find the object, but eventually give up. Was the object there or not?
      Show this thread
      4 replies 18 retweets 91 likes
      Show this thread
    9. Lucas Morin‏ @lucasmorin_eolc 31 Mar 2020

      Randomization process is questionable: (1) Randomization was "stratified by site" (page 4): I was under the impression that there was only one site... (2) With only N=62, the number of patients randomized to the treatment arm is exactly 31. A happy coincidence, I guess? /17

      3 replies 4 retweets 59 likes
      Show this thread
    10. David Gorski, MD, PhD‏Verified account @gorskon 2 Apr 2020
      Replying to @lucasmorin_eolc

      Also, there was no placebo used in the control group. (If there was, I couldn't find mention of it.) Thus, the study cannot truly be said to be "double blind," because patients would know if they were getting the drug or not, as would nurses, and, possibly, treating physicians.

      1 reply 0 retweets 6 likes
      David Gorski, MD, PhD‏Verified account @gorskon 2 Apr 2020
      Replying to @gorskon @lucasmorin_eolc

      Given that several of the outcomes (cough severity, for instance) are patient-reported and have a large subjective component, placebo effects could be the explanation for the effect seen on the outcomes that have a significant subjective component.

      3:23 PM - 2 Apr 2020
      • 5 Likes
      • Jane Muret Lucas Morin Dr Bruce Lobitz Blank Chris Croy
      1 reply 0 retweets 5 likes
        1. Lucas Morin‏ @lucasmorin_eolc 2 Apr 2020
          Replying to @gorskon

          Lucas Morin Retweeted Lucas Morin

          Completely agree. I added this "side note", but I guess it got lost in the thread... 👇https://twitter.com/lucasmorin_eolc/status/1245091433062830081?s=20 …

          Lucas Morin added,

          Lucas Morin @lucasmorin_eolc
          Side note n°4 While the pre-registered protocol mentions a placebo (starch pill 2x day), this is nowhere to be found in the paper. Yet, in the absence of placebo, the authors' claim that "neither the researcher nor the patients were aware of treatment assignment" is dubious.
          Show this thread
          0 replies 0 retweets 1 like
          Thanks. Twitter will use this to make your timeline better. Undo
          Undo

      Loading seems to be taking a while.

      Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.

        Promoted Tweet

        false

        • © 2021 Twitter
        • About
        • Help Center
        • Terms
        • Privacy policy
        • Cookies
        • Ads info