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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
Verified account
@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      David Gorski, MD, PhD Retweeted Sarah Karlin-Smith

      This is a strategy of the libertarian right that supports Trump. #RightToTry was never about speeding cures to the terminally ill. It was an first step in a long term plan to weaken the @US_FDA and lower the standards for drug approval. 1/https://twitter.com/SarahKarlin/status/1245063883800432640 …

      David Gorski, MD, PhD added,

      Sarah Karlin-SmithVerified account @SarahKarlin
      Trump's fascination with policies like right-to-try and his lack of appreciation of the scientific process appear s to be driving his response to COVID-19 pandemic -- potentially jeopardizing health and science. https://twitter.com/ddiamond/status/1245053233493618694 …
      2 replies 28 retweets 60 likes
      Show this thread
    2. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      I've been predicting for weeks now that the #COVID19 pandemic would be used as a pretext for the next step in loosening drug approval standards under the guise of "speeding cures to the people" and "loosening red tape." Hydroxychloroquine and chloroquine were the first salvo. 2/

      2 replies 7 retweets 23 likes
      Show this thread
    3. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      Unsurprisingly, @US_FDA caved and approved these drugs for #COVID19, even though there is a shocking paucity of evidence that they work in humans. One reason is simple: Set a precedent for lowering drug approval standards during a pandemic. 3/ https://sciencebasedmedicine.org/hydroxychloroquine-and-azithromycin-versus-covid-19/ …

      1 reply 5 retweets 15 likes
      Show this thread
    4. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      In this hydroxychloroquine and chloroquine are perfect as the next shot. They're already @US_FDA-approved for other indications, meaning that they could easily be prescribed off-label for other indications. That meant just getting docs to off-label prescribe builds pressure. 4/

      1 reply 4 retweets 14 likes
      Show this thread
    5. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      That's exactly what happened. Trump and @FoxNews promoted a handful of "miracle cure" stories plus a really dubious study or two by a French "maverick" scientist and Chinese anecdotal evidence, and, voilà! 5/

      1 reply 3 retweets 14 likes
      Show this thread
    6. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      Many doctors were revealed to be quite credulous and not very devoted to evidence-based medicine. They started prescribing the drugs willy-nilly. Some of them even started hoarding. Trump then rode to the rescue by persuading drug companies to make more available. 6/

      1 reply 3 retweets 15 likes
      Show this thread
    7. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      Meanwhile, political pressure was building on @US_FDA to approve the drugs for #COVID19, which the FDA duly did. It's no surprise that they did, either. FDA leadership had already been stocked with ideologues who also believed drug approval should be faster and less rigorous. 7/

      1 reply 3 retweets 15 likes
      Show this thread
    8. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      So now, chloroquine and hydroxychloroquine are FDA-approved for #COVID19, which means that states will now have a hard time trying to rein in the mad prescribing going on. 8/

      1 reply 4 retweets 13 likes
      Show this thread
    9. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      It will also mean that completing proper randomized clinical trials to see if they actually work will become near impossible. No patient will want to risk being randomized to the placebo control group. Why would they? The FDA approved the drugs. That must mean the work, right? 9/

      2 replies 5 retweets 21 likes
      Show this thread
      David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

      I now fear we will never really know if chloroquine and hydroxychloroquine have clinically meaningful activity vs. #COVID19 because the RCTs will likely never be completed. We'll never know which patients might benefit the most (if they work), what the optimal dose is, etc. 10/

      12:54 PM - 31 Mar 2020
      • 7 Retweets
      • 29 Likes
      • Lucas Fisher Denise Dickeson Bill kenny kentish bia Isthistherealworld? Marília Juste - 茹丽华 To aqui pra procrastinar Eli Vieira
      2 replies 7 retweets 29 likes
        1. New conversation
        2. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

          A whole lot of people will be placed at risk for serious cardiac arrhythmia, though. Actually, that's happening now, for no known benefit. 11/

          1 reply 3 retweets 15 likes
          Show this thread
        3. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

          Trump doesn't care, though. His libertarian anti-regulation, anti-FDA backers don't care. They've notched a "victory" against the deep state, the regulatory state. They've set a precedent. 12/

          1 reply 2 retweets 17 likes
          Show this thread
        4. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

          Next step: Get the FDA to super fast track drugs that aren't currently approved and approve them for #COVID19 with inadequate testing. Anyone who's been paying attention knew that this would be their next move, all in the name of "saving patients." 13/

          1 reply 4 retweets 27 likes
          Show this thread
        5. David Gorski, MD, PhD‏Verified account @gorskon 31 Mar 2020

          We'll pay a price for this in the future, when drugs are approved based on much lower evidence standards and less rigorous safety testing. Don't worry though. The free market will decide. That's what the anti-regulation right always says. 14/14

          4 replies 5 retweets 36 likes
          Show this thread
        6. End of conversation
        1. John Mashey‏ @JohnMashey 31 Mar 2020
          Replying to @gorskon

          John Mashey Retweeted Vineet Chopra

          HCQ Comment in interesting thread from your state:https://twitter.com/vineet_chopra/status/1244998590352642049?s=20 …

          John Mashey added,

          Vineet ChopraVerified account @vineet_chopra
          Really have not seen any clinical benefit from hydroxychloroquine. Rather have seen a lot of GI ADRs and LFT bumps coming out of it. Not sure this has as much of a role in disease care TBH.
          Show this thread
          0 replies 0 retweets 0 likes
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