On Friday, Prof. Didier Raoult posted another study of azithromycin and hydroxychloroquine used against COVID-19. It is a single arm observational study of patients with mostly mild (or even asymptomatic) disease that is painfully uninformative.https://sciencebasedmedicine.org/hydroxychloroquine-and-azithromycin-versus-covid-19/ …
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100% agree with you. I get off-label prescribing. It happens. I have participated in this with good clinical rationale in one-off patients. High-quality evidence-based medicine is needed for this pandemic, not quackery.
Thanks. Twitter will use this to make your timeline better. UndoUndo
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I keep sharing the information about clinical trials. Problem is health care providers tend to be too busy right now to participate. I guess... or maybe they are unimpressed by the current data?
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If the hospital MD's have access to a clinical trial, they are doing themselves a disservice by not using that. The FDA emergency approval and supplies are only for patients without access to trials. I get being busy; however, trials should be the SOC right now.
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You don’t think somebody will do an SAR series on them to figure out MOA for off target effects?
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That will not usurp the need for clinical outcomes. This is not like a biologic that we have direct knowledge of an MOA that can be replicated over time. Many drugs that have an MOA know still fail in treating patients.
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Sorry for french version but we’ll have a 1300 cases study, double blind placebo and I guess with a serious randomisation & evaluation herehttp://www.lefigaro.fr/flash-actu/covid-19-une-vaste-etude-pour-clore-le-debat-sur-la-chloroquine-20200331 …
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To stay consistently on message, they should have randomized twice the number of patients and reported that. But very important in framing the hypothesis that is being generated and studied in larger trials. My note as a pharmacist is the patient that developed prolonged Qt.
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