The study cited by @khoekstra where hydroxychloroquine and azithromycin were claimed to be able to "cure" #COVID19 had such glaring methodological flaws and downright incompetent analysis that it really showed in essence nothing. 2/https://sciencebasedmedicine.org/are-hydroxychloroquine-and-azithromycin-an-effective-treatment-for-covid-19/ …
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The only currently reported clinical trial of chloroquine to treat
#COVID19 was a negative study. 3/ https://www.forbes.com/sites/tarahaelle/2020/03/25/chloroquine-use-for-covid-19-shows-no-benefit-in-first-small-but-limited-controlled-trial/ …5 replies 6 retweets 28 likesShow this thread -
Granted, it was a small study; so it's possible there's an effect that will show up in the larger studies under way, but, given this result, there is no reason to forego clinical trials and give these drugs off trial now. 4/
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There are also real world consequences to the hype around these drugs. For one thing, they are not benign. The doses used in the existing clinical trials were high. Although rare, these drugs can cause fatal arrhythmias. 5/
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For another thing, the hype has led to hoarding, making it hard for patients who actually benefit from these drugs to get them. These patients suffer if these drugs are diverted before we know if they work. 6/
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Given that background, it was entirely reasonable of the state to crack down on the prescribing of these drugs, particularly outside of hospitals, to prevent or treat
#COVID19. 7/1 reply 1 retweet 25 likesShow this thread -
The narrative that the state is somehow hampering the efforts of doctors in Michigan to treat
#COVID19 by restricting the use of these drugs is partisan propaganda, not fact. 8/1 reply 2 retweets 32 likesShow this thread -
Basically, this
@DetNewsOpinion op-ed by@khoekstra is nothing more than a deceptive attack on what was a reasonable order rooted in science and medicine. Quelle surprise, though, given that it's the Detroit News and Hoekstra's with@PacificLegal. 9/92 replies 2 retweets 28 likesShow this thread -
Whoa. I've changed my opinion. I used to think that the study cited by Hoekstra was just incompetently designed, carried out, and analyzed. Now I think it was more likely scientific fraud. 9a/9https://forbetterscience.com/2020/03/26/chloroquine-genius-didier-raoult-to-save-the-world-from-covid-19/ …
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And he now has another study. Of course, it’s not randomized. It’s single arm. To my initial read, it doesn’t really show much of anything about whether hydroxychloroquine and azithromycin work against #COVID19. https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-IHU-2-1.pdf …
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Muscaria Retweeted PDDrKatjaBaerenfaller
Have you seen this? Another terribly flawed paper:https://twitter.com/jaggakatja/status/1243343083086983168 …
Muscaria added,
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Raoult is just have having fun with people like you who do not understand maths. He just "forgot" to mention in the articles that average covid duration was 20 days in China. Read the articles again.
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