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gorskon's profile
David Gorski, MD, PhD
David Gorski, MD, PhD
David Gorski, MD, PhD
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@gorskon

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David Gorski, MD, PhDVerified account

@gorskon

Surgeon/scientist promoting science in medicine and exposing quackery. Editor of Science-Based Medicine. My opinions do NOT represent those of my employers.

Michigan, USA
sciencebasedmedicine.org
Joined October 2009

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    1. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      Currently according to http://ClinicalTrial.gov , 6 trials using CQ or HCQ are underway for the treatment of prophylaxis of #COVID19 https://clinicaltrials.gov/ct2/results?cond=covid19&term=chloroquine&cntry=&state=&city=&dist=&Search=Search …pic.twitter.com/7lp71Lyh7i

      1 reply 58 retweets 186 likes
      Show this thread
    2. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      But the one that interests me is the French open-labeled non randomized clinical trial on HCQ + Azithromycin against #COVID19 infection, largely publicized. Details are here https://www.mediterranee-infection.com/wp-content/uploads/2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf …pic.twitter.com/KPbaUgIgAf

      6 replies 64 retweets 197 likes
      Show this thread
    3. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      This is a small clinical trial (n=42 in total). Inclusion criteria in short moderate #COVID19 infection (positive viral load). Exclusion criteria, allergy, long QT syndrome.... In total 42 enrolled, 6 drop out including 3 in ICU. Total 20 HCQ vs 16 controls.

      2 replies 41 retweets 165 likes
      Show this thread
    4. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      Clinical presentation seemed similar between HCQ & control but sample size is so low, difficult to conclude really. Seriously underpowered. Outcome from the study is based on viral load only and not on clinical outcome and I can see a major flaw here as clinical outcome critical.pic.twitter.com/XgaDnm34bh

      5 replies 78 retweets 321 likes
      Show this thread
    5. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      So 16 patient received no treatment, 14 patients received HCQ only (200 mg/ day) and 6 patients received HCQ (200 mg/day) + Azithromycin to prevent surinfection (on clinical judgement). The treatment was for 10 days and outcome on viral load (nasopharyngeal swabs)

      4 replies 34 retweets 150 likes
      Show this thread
    6. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      The results showed a reduction of the viral load from HCQ and HCQ + Azithromycin treated patients compared to controls. Looks spectacular but wait .... No error base on these graphs. So I looked at the suppl datapic.twitter.com/UdN2y6779X

      7 replies 62 retweets 233 likes
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    7. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      Looking at supplementary Table 1, most of the controls had viral load qualitatively detected or the PCR was not done !!!! . Only 4 out of 16 controls had a proper measure of the viral load !!!! This is insane !pic.twitter.com/hDhKewVcTu

      25 replies 173 retweets 661 likes
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    8. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      In short, all this hype on the clinical trial is based on a open label, non randomized and underpowered clinical trial on HCQ treatment against #COVID19 with viral load as an outcome that was not properly measured in 2/3 of the control cohort !!!

      15 replies 271 retweets 712 likes
      Show this thread
    9. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      So to answer the question: What is the evidence of justifying using HCQ or CQ as a prophylactic or curative treatment against #COVID19. The simple or short answer is NONE. To ascertain it, we need a proper and powered randomized clinical trial

      30 replies 384 retweets 866 likes
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    10. Dr Gaetan Burgio, MD, PhD.‏ @GaetanBurgio 20 Mar 2020

      While I understand we are in a #COVID19 pandemic, there is no reason or whatsoever to throw away all the evidence based medicine and not doing rigorous science or a randomized clinical trial !

      53 replies 167 retweets 871 likes
      Show this thread
      David Gorski, MD, PhD‏Verified account @gorskon 22 Mar 2020
      Replying to @GaetanBurgio

      It's also interesting to note how they cultured the virus. They filter sterilized the aspirate in saline, applied it to Vero E6 cells, then waited for cytopathic changes, at which point they did EM on the supernatant looking for virus particles before doing RT-PCR. I'm confused.

      12:47 PM - 22 Mar 2020
      • 2 Likes
      • Kimbra Cable A very tired gal
      0 replies 0 retweets 2 likes

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