And my personal favorite: the Francis Field Trial for Salk's polio vaccine with 1.8 million children enrolled. The largest RCT ever done and with a saline placebo no less. Required 300,000 volunteers. Just extraordinary.
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When I quoted the Salk Trials to an antivaxxer online he asked for the peer reviewed paper.
"Dude it's in every textbook and there is an entire series of books dedicated to it."
"Haha no peer reviewed publications GOTCHA!" - Show replies
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