Mine best defense was neoadjuvant chemoradiation, surgery at a high-volume cancer center, and some more chemo for good measure; all this depended on a team of oncologists and other clinicians. Humor sure didn't prevent me from getting cancer.
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One of the saddest cases I remember from the JHU pancan board was an older widower left destitute and spouseless after taking a second mortgage, cashing in retirement, etc. for snake oil treatments (IV VitC, coffee enemas) his wife wanted.
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