What do I do for fun on a Friday night? Hang out with the wildchilds of medicine: the #ObGyn crowd.
To turn this party into an educational event, here is a thread on #pregnancy & the #heart. #WomensHeartHealth #biom4180
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Increased cardiac output in pregnancy could be because the heart contracts more forcefully. Unfortunately the data are unclear on whether this happens or not. Source: Savu et al, 2012.pic.twitter.com/Mv547Hde4u
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The heart also beats faster in pregnancy. An elegant basic research study by Dr Céline Fiset's group shows this might be because of a protein called HCN. Graph: Hall et al 2011.pic.twitter.com/3qEk5VA5ge
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HCN is a channel in the SA node. The SA node sets the heart's beating rate. Dr Fiset's lab showed this protein increases in pregnant mice & increases heart rate.pic.twitter.com/Nz6kArNwiJ
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Even though the heart is functioning at a higher level, blood pressure in pregnant women normally doesn't rise & may actually decrease.pic.twitter.com/OR8W9iYAr3
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There are many changes that could explain the decrease in blood pressure. Kristiansson & Wang showed that increased levels of progesterone & relaxin are sufficient to drive these changes.https://academic.oup.com/humrep/article/16/1/13/3113872 …
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About 1% of pregnancies are associated with a heart problem. In some cases they are not previously diagnosed, but the increased load placed on the heart unmasks problems. http://healthinfo.uclahealth.org/Search/90,P02439 …
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Peri-partum cardiomyopathy is one of the leading causes of non-obstetric death associated with pregnancy. Why & how this happens is poorly understood. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.115.020491 …
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For most women the cardiac changes are significant, but not pathological, and generally reverse after birth. For more information check out this great review by Drs Chung & Leinwand.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941597/ …
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Remember: I am not a real doctor, I just pretend to be one on Twitter. If you want more
#OBGYN info follow Twitter's experts@DrJenGunter@FionaMattatall@BirthControlDoc@DrLesleaPrikaži ovu nit
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