Here is an example of what I'm talking about: https://www.sciencedirect.com/science/article/pii/S0896627312004266 … One can't discover medial axis coding neurons until one formulates the concept of a medial axis skeleton.
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I'm looking for examples in the history of neuroscience where no one thought to measure something until a theory posited that it should exist (i.e., empirical phenomena that were effectively invisible in the absence of theory).
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Distributional reinforcement learning This is new and to be established but this could be a good example for that. I wished that we would have thought about it from the data but... https://www.nature.com/articles/s41586-019-1924-6.epdf?author_access_token=ASaTR4qMH190wSHiKLjQ7NRgN0jAjWel9jnR3ZoTv0OgnvLoVhK46-VND2gsGkjz36rZENj3hLKoFtZ6yylssm1cot8UrjoCWaDrIBKZs-uF0doLijXxV5GpU93RmqJeFMCQ_BzuM9Sr7acs_dVtKg%3D%3D …
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Yes, terrific example!
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I am fond of this recent one (2017), by
@weixx2https://www.pnas.org/content/early/2017/09/01/1619153114 … -
That is a great example for psychophysics. Did it make any brain phenomena visible that were previously invisible?
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Margin perhaps.
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Someone measured a margin in the brain?
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My first neuroscience paper: a model of striatum spiny neurons that could become bistable under dopamine. It was a theory paper. One referee objected: 'you cannot predict what has not been observed'. A classic! I told myself: Toto, I've a feeling we're not in physics any more.
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I hope you replied: ‘You can ONLY predict what has not be observed’.
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Ionic theory of excitability. One I like is Hodgkin's experiment where he puts a squid axon in oil to show that it slows down conduction. More famous is single-channel recordings with patch-clamp, and before that, noise analysis to test ionic channel theory.
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yes! noise analysis. Until Anderson & Stevens (1973), people didnt realize that endplate noise could be used to infer the single channel conductance of an ACh receptor. https://www.ncbi.nlm.nih.gov/pubmed/4543940
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