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Gabor Erdosi

@gerdosi

Study reader ǁ Molecular biologist ǁ Industrial biotech ǁ Metabolic profiling. R&D consultant. Main scientific interest: intestinal immunometabolic interactions

Science & TechnologyTissue residentgiftapp.com/gerdosiJoined February 2012

2,676 Following

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Gabor Erdosi 🧩📄📊🧭’s Tweets

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Gabor Erdosi

@gerdosi

Jul 15, 2019

Don't be misled: "The total area of the human adult gut mucosa is not in the order of tennis lawn, rather is that of half a badminton court." (Reason for sharing: total mucosal surface of the GI tract ∼32 m2, of which only 2 m2 is the large intestine.)

tandfonline.com

Surface area of the digestive tract – revisited

Background. According to textbooks, the human gut mucosa measures 260–300 m2, that is, in the order of a tennis court. However, the quantitative data are incomplete and sometimes conflicting. O...

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Gabor Erdosi

@gerdosi

It’s still previous infection that works best. I bet multiple infections over years work even better. Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by 4 doses of parental mRNA vaccine or a BA.5-bivalent booster

biorxiv.org

Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by 4 doses of parental mRNA...

The newly emerged SARS-CoV-2 Omicron BQ.1.1, XBB.1, and other sublineages have accumulated additional spike mutations that may affect vaccine effectiveness. Here we report neutralizing activities of...

“If Covid didn’t cause chronic symptoms to occur in some people, it would be the only virus that didn’t do that.” “A PROPORTION — USUALLY AROUND 30 % — OF SURVIVORS OF ANY MEDICAL CONDITION REPORT HIGH RATES OF FATIGUE, SLEEP DISTURBANCE, BRAIN FOG, PAIN, DEPRESSION, AND ANXIETY”

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Then Prof. Hotez can most likely list the many coronaviruses that had been coming before science/scientists started tinkering with those viruses? I know about one(!) that’s *suspected* to have jumped >a century ago from cows. Then for 114 years nothing, but since 2003 three CoVs?

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Prof Peter Hotez MD PhD

@PeterHotez

Nov 1

Why yes in fact I do: as someone who has developed coronavirus vaccines SARS MERS COVID for >10 yrs, I can promise you this is just the start. More deadly CoVs are coming unless the US Congress can begin organizing themselves away from conspiracies and support science/scientists twitter.com/deadliftcapita…

Gabor Erdosi

@gerdosi

18h

I doubt that this is limited to microglia, and if indeed generalizable this could represent a strong link to metabolic diseases. “purified SARS-CoV-2 spike glycoprotein activated the NLRP3 inflammasome in LPS-primed microglia, in a ACE2-dependent manner.”

nature.com

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Molecular Psychiatry - SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Gabor Erdosi

@gerdosi

Nov 1

Some perspective on this. It’s been known that other viral infections can cause dysbiosis in both the lungs cell.com/cell-reports/f and the gut microbiomejournal.biomedcentral.com/articles/10.11 It’s a two-way street where preexisting dysbiosis can contribute to more severe outcomes nature.com/articles/s4138

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Eric Topol

@EricTopol

Nov 1

Covid infections disrupt the gut microbiome and increase vulnerability to secondary bloodstream infections nature.com/articles/s4146 @NatureComms @Lucie_Bernard_R @CadwellLab @YaleIBIO @VirusesImmunity

Gabor Erdosi

@gerdosi

Oct 31

Somehow I do not share the main concern (cited below) about this ‘novel’ condition. 🤨 “This potentially serious complication has been associated with serious harm, arguably most prominently through promotion of vaccine hesitancy”

ahajournals.org

Vaccine‐Triggered Acute Autoimmune Myocarditis: Defining, Detecting, and Managing an Apparently...

mRNA vaccination results in 3+ months of shingles. Lesions contained spike protein. "persistent VZV infection following mRNA.. vaccination.. presence of spike protein in the affected skin. Further vigilance of the vaccine side effect.. is warranted." onlinelibrary.wiley.com/doi/epdf/10.10

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I do recognize that for the masses there must be little to no difference in facing a conspiracy theorist or a pattern recognizer weirdo. That’s why the immediate reaction from obfuscatory masters is calling everybody who evaluates information differently a conspiracy theorist.

Growing up in propaganda state, it seems that I’m still sensitive to these practices. Or is it just a different mindset that makes some of us recognize certain patterns already in limited information? Already a small shift toward irrationality is one of the strongest triggers.

GIF

read image description

ALT

Here’s the link to the actual study if you still have some appetite left for such science.

zslpublications.onlinelibrary.wiley.com

ZSL Publications

We review and document nose picking and mucophagy in primates and present the first occurrence of this behaviour in a strepsirrhine primate with a unique video showing an aye-aye picking its nose....

Here I introduce you the champions of nose-picking. Their finger reaches down the throat… I’m not sure why the researchers are uncertain about the benefits, just think of the ‘lung-gut axis’. (I hope I picked a matching background color for the excerpt😉) theguardian.com/world/2022/oct

“OSA could be predicted with 99% precision using anthropometric parameters and AT values from the MRI. Age, neck circumference, midsagittal and parapharyngeal tongue fat values, and BMI were the most vital parameters in the prediction.” AT: adipose tissue

mdpi.com

The Predictive Role of the Upper-Airway Adipose Tissue in the Pathogenesis of Obstructive Sleep...

This study aimed to analyse the thickness of the adipose tissue (AT) around the upper airways with anthropometric parameters in the prediction and pathogenesis of OSA and obstruction of the upper...

Gabor Erdosi

@gerdosi

Oct 26

Are these reduced in metabolic disease, too? “polyfunctional neutralizing and non-neutralizing breadth, magnitude, and coordination diminish with age.” BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish… cell.com/cell-reports/f

A mechanism of persistent, “homeostatic”, infection is uncovered. ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection cell.com/cell-reports/a

I’m going to help you with a little bit of extra explanation in green (as well as with a study link). link.springer.com/article/10.100

Confirmation in another preprint. “Our data show that BA.5 NAb titers were comparable following monovalent and bivalent mRNA boosters.” Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters

biorxiv.org

Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters

Waning immunity following mRNA vaccination and the emergence of SARS-CoV-2 variants has led to reduced mRNA vaccine efficacy against both symptomatic infection and severe disease. Bivalent mRNA...

To be fair our understanding has improved vastly over the last two years or so, and now it’s way more commonly accepted that immune evading variants mostly develop in immunocompromised hosts during chronic infections. Still, blaming of the unvaccinated was ubiquitous.

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Who’s the variant factory here? “the relatively higher intra-host diversity among vaccinated individuals, and the detection of immune-escape mutations, despite rare, suggest a potential vaccine-induced immune pressure in vaccinated individuals.” cell.com/iscience/abstr

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Little critter superheroes. 🐝 “honeybee swarms directly contribute to atmospheric electricity, in proportion to the swarm density. …the charge contribution of some insect swarms will be comparable with that of meteorologically induced variations.” cell.com/iscience/abstr

Gabor Erdosi

@gerdosi

Oct 24

Eight mice, twenty-one humans, and the ambivalent rooster. Sorry, booster. Reads like a great bedtime story.

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Beyond 8 mice! “When given as a fourth dose, a bivalent mRNA vaccine targeting Omicron BA.4/BA.5 and an ancestral SARS-CoV-2 strain did not induce superior neutralizing antibody responses in humans… compared to the original monovalent vaccine formulation”

biorxiv.org

Antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot

The SARS-CoV-2 Omicron variant and its numerous sub-lineages have exhibited a striking ability to evade humoral immune responses induced by prior vaccination or infection. The Food and Drug Adminis...

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Noble prize laureate’s publications are under fire. Extensive image tinkering and several publications being already retracted suggest “intention to mislead”.

nature.com

Dozens of papers co-authored by Nobel laureate raise concerns

Nature - Concerns about image integrity have so far led to 17 retractions, corrections or expressions of concern for papers co-authored by geneticist Gregg Semenza.

Browse through this review. It’s scandalous that real experts remained silent when SARS2 appeared and half the world was left in the dark about pathogenesis and treatment options. More was known from SARS and MERS than what most doctors understand now.

link.springer.com

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopath...

Seminars in Immunopathology - Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and...

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Gabor Erdosi

@gerdosi

Oct 24

I’m going to help you with a little bit of extra explanation in green (as well as with a study link). link.springer.com/article/10.100

If you search my handle for “mimicry” several of the requests for explanation of below findings from leading virologists and other experts can be found. I never got an answer. No reply, no blocking, nothing. Just silence. I still can’t come up with anything else but the obvious?

I’ve been told repeatedly how important it is to clean the air in the rooms I’m in. But I’ve been doing that all my life, and you, too.

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Gabor Erdosi

@gerdosi

Feb 18, 2021

Replying to @Kevin_McKernan

This is the filtering job the nose does. Particle size changes across typical masks can be substituted in. Consequences of reducing particle size are also highlighted. Taken from atsjournals.org/doi/full/10.15

Gabor Erdosi

@gerdosi

Oct 22

While I don’t like gain of function, I do love loss of function research, especially which yields live attenuated virus vaccine candidates. Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity cell.com/iscience/abstr

🤔 🧐 “the SARS-CoV-2 spike glycoprotein is phenetically more similar to humans and mice than to its coronavirus “cousins”.” Zoonotic transmission my a.se.

link.springer.com

Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implications for...

Immunologic Research -

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Kristian Andersen's "debunking" of the controversial lab engineering preprint consists of pointing out that each of the supposed splitting-points in the genome has a natural precedent (in different viruses). But I think this is missing the point. The preprint actually...

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🚨JAMA: Große skandinavische Studie (23 Mio) vergleicht Myokarditis-Risiko nach Impfung mit dem Risiko nach einer Covid-Infektion. Entgegen häufiger Behauptung ist Impfrisiko um ein Vielfaches (6-28x) höher - das der Infektion kommt für Geimpfte obendrauf.jamanetwork.com/journals/jamac

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“We report a high likelihood that SARS-CoV-2 may have originated as an infectious clone assembled in vitro.” 🧐 🤔 Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2 biorxiv.org/content/10.110

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Gabor Erdosi

Retweeted

Christian Thoma MSc PhD

@DrChristianThom

Oct 20

It's not just what you eat that influences your #gut #microbiome, but also the medication (not just antibiotics). We now need to be thinking about that more carefully when studying #diet, #prebiotics, #probiotics, #gutbrainaxis and the #microbiota #Gastroenterology

@gerdosi

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Jonathan G. Stine, MD MSc, FACP

@JonathanStineMD

Oct 19

Even more reason to stop and think of downstream consequences before we prescribe medications… non antimicrobial meds also impact the microbiome, especially in the setting of polypharmacy

twitter.com/AGA_Gastro/sta…

Delighted to share my new review

@NatMetabolism

"metabolic responses against viral infections” This is thought-provoking article and will challenge our mindset, forcing us to think in different ways on how the body fights infections. nature.com/articles/s4225

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Everybody keeps talking about antibody-escaping variants… Nice work from Andrew Godking is showing how magnitude of T cell response against SARS-CoV2 structural proteins (M,NP and Spike) correlates with protection against COVID-19 more than Ab. Go T cells

nature.com

Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines...

Nature Communications - The presence of SARS-CoV-2-specific antibodies alone is not an accurate determinant of immunity. In this work, the authors investigate if whole-blood based measurement of...

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Gabor Erdosi

@gerdosi

Oct 19

Almost at the 2y anniversary…

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Gabor Erdosi

@gerdosi

Oct 24, 2020

Replying to @rugbychris3

I expect that first wave of vaccines could have a substantial severity-, but only modest transmission reducing effect. Nasal immunization with a multiple antigen vaccine seems a much better option.

…of the evolution/adaptarion of human coronaviruses. All this two years ago.

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Gabor Erdosi

@gerdosi

Dec 19, 2020

Antigenic evolution of the spike, especially the receptor binding domain, may explain waning immunity against human coronaviruses. As discussed earlier, some signs are already there for SARS-CoV-2, and is expected to be accelerated by spike-only vaccines. twitter.com/gerdosi/status

This could be predicted based on our knowledge of general (respiratory) immunity as well as…

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Gabor Erdosi

@gerdosi

Oct 27, 2020

1/ Thread on immunity in the respiratory system: how it does and doesn't work (i.e. myths), simplified as much as I could. I’ll use the apropos of a new press release by Imperial College. To avoid mainstream media fantasies, let's use the original piece. imperial.ac.uk/news/207333/co

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Gabor Erdosi

@gerdosi

Oct 18

Check out this slideshow and digest conclusions.

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Bloom Lab

@jbloom_lab

Oct 18

Here are a few slides that elaborate on this topic: slides.com/jbloom/sars2-v

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