Gabor Erdosi     

@gerdosi

Study reader ǁ Molecular biologist ǁ Industrial biotech ǁ Metabolic profiling. Interests: mucosal immunity, immunometabolism. V. Omega Pro Max

Sofa, iPad in hand
gabor.erdo.si
Joined February 2012
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  1. Pinned Tweet
    15 Jul 2019

    Don't be misled: "The total area of the human adult gut mucosa is not in the order of tennis lawn, rather is that of half a badminton court." (Reason for sharing: total mucosal surface of the GI tract ∼32 m2, of which only 2 m2 is the large intestine.)

    16 replies 49 retweets 252 likes
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  2. 13 hours ago

    Data doctoring by a pharmaceutical vassal state to show the effectiveness of booster shots. Recall immune responses take way less time than primary inoculation, so there’s absolutely no scientific reason to leave out 12 days —more than half of the infections!— following the boost

    4/ Actually, they excluded more than half of the infections! 13K infected (Fig 1), only 5,373 analyzed (Table 2).
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    7 replies 69 retweets 187 likes
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  3. 15 hours ago

    Other studies at least correct for prior infection, not this one. “previously infected persons who have developed natural immunity are not removed from the person-time at risk.”

    13 retweets 76 likes
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  4. 15 hours ago

    The typical fallacy of calculating vaccine effectiveness: “People who received no vaccine ***or one dose less than 14 ago*** are categorized as unvaccinated.” The period when vaccination ~doubles risk is added to ‘unvaccinated’. Great science —not.

    20 replies 180 retweets 475 likes
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  5. Sep 17

    Common amtibody evading variants arise in monoclonal Ab treated patients in days. “Participant B2_3 showed emergence of E484K and viral rebound between study days 3 and 7. Participant B2_2 showed emergence of a mixed population of E484K and E484Q viruses”

    1 reply 11 retweets 35 likes
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  6. Sep 17

    “monocytes are the main contributors to the transcriptional differences in these infections. Monocytes from COVID-19 patients share hyperinflammatory signatures with HIV infection and immunosuppressive signatures with sepsis.”

    Text Shot: We identify ten hyperinflammatory cell subtypes in which monocytes are the main contributors to the transcriptional differences in these infections. Monocytes from COVID-19 patients share hyperinflammatory signatures with HIV infection and immunosuppressive signatures with sepsis.
    12 replies 49 retweets 114 likes
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  7. Sep 16

    Depending on to which region of common cold coronavirus spike you had dominant antibody responses, the recall reaction (the original antigenic sin) can either confer protection or can be deleterious.

    7 replies 17 retweets 76 likes
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  8. Sep 16

    Canonical ADE still seems unlikely. "neutralizing activity of CCP correlated best with higher titers of anti-S IgG antibodies, the neutralizing titer was not affected when Fc receptors were present on target cells."

    Replying to @limits_stop
    Non-canonical ADE most likely already occurs in Delta infections. Classic ADE, when phagocytes are productively infected by virus-Ab complexes taken up via FcR, still seems unlikely.
    4 replies 5 retweets 36 likes
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  9. Sep 16

    “among patients with ARDS and COVID-19, insulin resistance is the prevalent cause of hyperglycemia, independent of glucocorticoid treatment, which is unlike patients with ARDS but without COVID-19, where pancreatic beta cell failure predominates.”

    3 replies 14 retweets 55 likes
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  10. Sep 15

    The authors developed a dual antigen vector vaccine and call it multi-antigen and second generation. What was left out is running a real world scenario where the animals received a 1st gen mRNA or AdV immunization prior to the 2nd gen.

    5 replies 8 retweets 34 likes
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  11. Sep 15

    Another nice longitudinal study shows that children can mount a robust early innate response and resolve towards proper adaptive activation. Guess what impairs proper innate immune responses? Diseases of innate immunity, also called metabolic diseases.

    Text Shot: • Innate response against SARS-CoV-2 is robust in children despite limited symptoms • Resolution of inflammation and onset of B cell response occurs faster in children • Antibody response is not compromised by the shorter antiviral inflammatory response
    3 replies 81 retweets 232 likes
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  12. Sep 15

    Not mentioned in the abstract, but the immune imprinting they talk about is obviously original antigenic sin. The more ‘suboptimal’ (i.e. outdated antigen) jabs one gets the more challenging the identification of efficacy improving strategies becomes.

    21 replies 115 retweets 231 likes
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  13. Sep 14

    Lipopolysaccharides are important signaling molecules, kind of ‘bacterial cytokines’. The most likely mechanism that underlies opposing effects is competition @ TLR4; penta-acylated forms being very mild agonists, this way outcompeting the highly inflammatory hexa-acylated forms.

    Metabolic endotoxemia is dictated by the type of lipopolysaccharide
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    1 reply 5 retweets 36 likes
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  14. Sep 14

    The same negative association exists between intestinal parasites, e.g. helminths, and metabolic diseases. It doesn’t take much brain power to place metabolic issue-based increased susceptibility to severe disease into the picture and see that these are closely connected.

    Mr Erdosi, this might be interesting to read:
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    3 replies 10 retweets 38 likes
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  15. Sep 13

    Higher pressure, more rapid adaptation? “Protein-coding mutations in S1 are temporally-clustered and, in 2021, the ratio of nonsynonymous to synonymous divergence in S1 is more than 4 times greater than in the equivalent influenza HA1 subunit.”

    9 replies 31 retweets 94 likes
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  16. Sep 13

    An update 13 months in (A side note: in most of the countries affected, not COVID, but the disproportionate mitigation practices disrupt preventive activities.)

    6 retweets 26 likes
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  17. Sep 13

    Reducing R from 7 to 6 by optimally executed contact tracing is not a meaningful intervention, because that is still double of what the original virus was. At current rates of infection and vaccination contact tracing should be scrapped.

    2 replies 16 retweets 73 likes
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  18. Sep 12

    Why don’t we hear much more about tissue resident, especially CD8+, memory T cells? Great editorial & a selection of nice studies. Resident Memory T Cells – Guardians of the Balance Between Local Immunity and Pathology – The Minority Report

    Text Shot: Given the crux of vaccinating the elderly to relieve stresses of the current pandemic, it may therefore be fortuitous that intramuscular jabs are not expected to induce local T cell immunity to respiratory viruses
    7 replies 55 retweets 136 likes
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  19. Retweeted
    Sep 11

    (1/n) BMJ: Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19" "we detected SARS-CoV-2 nucleocapsid protein (NP) in the colon, appendix, ileum, haemorrhoid, liver, gallbladder and lymph nodes...

    5 replies 34 retweets 72 likes
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  20. Sep 11

    Metabolically inflexible people fail to adjust their fat oxidation to nutrient availability. (Likely due to impaired stimulated lipolysis?) Their RQ is almost a flat line over 24 h as measured in this study.

    5 replies 12 retweets 64 likes
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  21. Sep 10

    Infection induced humoral immunity is qualitatively superior to that triggered by vaccination. Naturally Differential antibody dynamics to SARS-CoV-2 infection and vaccination

    Text Shot: The composition of antibody neutralizing activity to variant relative to original virus also differed between groups, with infection-induced antibodies demonstrating greater relative breadth. Differential antibody durability trajectories favored COVID-19-recovered subjects with dual memory B cell features of greater early antibody somatic mutation and cross-coronavirus reactivity.
    6 replies 63 retweets 170 likes
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