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1) I am very worried about Omicron and inactivated vaccines. According to early data from the UK, 2x AstraZeneca or 2x Pfizer provides little protection from symptomatic disease. VE with inactivated vaccines is generally lower (as shown e.g. in Brazil: https://www.medrxiv.org/content/10.1101/2021.08.21.21261501v2.full.pdf …)
2) Its also unclear how other vaccines like Sputnik, Soberana-2, Cansino, Zydus Cadila's DNA vaccine etc. will hold up. If updated vaccines are needed (which now seems likely), can this be done quickly for non-vector and non-mRNA vaccines?
3) Especially for inactivated vaccines I am very worried. They are grown on Vero cells. It is not clear yet if Omicron has robust growth/yields on Vero. If the virus grows less well, that means less vaccine can be produced.
4) If we think about Omicron, we need to think globally. Yes, boosters seem to protect and mRNA vaccines can be adapted to Omicron. But these are all luxuries that are not accessible to most people on this planet. More boosters in high income countries mean less vaccines for...
5)....other regions. Omicron specific mRNA vaccines that are produced for high income countries will also lead to reduced availability for LMICs. We need to think about how to solve this. We are not safe until all of us are safe - Omicron has demonstrated that.
@yamilethra y tu deseo se hizo realidad: uno de los top sacando su punto de vista respecto a varias vacs que no hayan sido mRNA
Obviamente aquí se está refiriendo a un update y no a booster pero es chido que alguien top plantee un asunto de interés para países como@Mx y muchos otros
The data also shows that the booster shot provides greatly increased immune response.
Walks right by without even saying hi.
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