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florian_krammer's profile
Florian Krammer
Florian Krammer
Florian Krammer
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@florian_krammer

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Florian KrammerVerified account

@florian_krammer

Viruses, viruses, viruses and vaccines. V3=vaccinated three times Professor at the Department of Microbiology Icahn School of Medicine at Mount Sinai

New York, NY
labs.icahn.mssm.edu/krammerlab/
Joined February 2016

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    Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

    1) The low efficacy of the Novavax vaccine candidate against the B.1.351 is concerning. However, the data is also reassuring in many ways. First, the vaccine itself worked very well against the 'old' SARS-CoV-2 variants and the B.1.1.7 (UK) variant. Also, the vaccine...

    4:25 PM - 28 Jan 2021
    • 658 Retweets
    • 2,418 Likes
    • @BitchyBiologist Hoelder1in - 114600 (eine*r von 726) Aviva Gabriel Healight™..Cedars-Sinai, MAST & Aytu Bio followers Sakamoto-san N.D. Sabate PepeDePablos Leo Swadling Juilee Thakar
    58 replies 658 retweets 2,418 likes
      1. New conversation
      2. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        2) ...seems to work almost as well in HIV positive individuals as in HIV negative individuals. And, vaccine efficacy against B.1.351 seemed markedly reduced, but still present. This was against symptomatic disease in general. It is very likely, that the efficacy against....

        9 replies 39 retweets 431 likes
        Show this thread
      3. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        3)...severe disease is much higher. There are also some other things we can learn here. Novavax was reporting very high neutralization titers from their initial clinical phases, around 1:3500. Now, we see that there is a reduction in neutralization against B.1.351....

        4 replies 37 retweets 409 likes
        Show this thread
      4. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        4)...of about 6-10-fold (depending on the preprint, for some even higher). That would result in a 1:350 neutralization titer. That's around the titers that Pfizer reported against the wild type strain. This could mean two things: The readouts of different neutralization assays...

        7 replies 30 retweets 311 likes
        Show this thread
      5. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        5)...run in different labs are not comparable. Or, neutralizing antibodies are not the (only) correlate of protection. Or both. But it would be good if independent labs could run sera from several of the current vaccine trials and compare directly. Another important point is....

        8 replies 28 retweets 385 likes
        Show this thread
      6. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        6)....and that it may be hard to extrapolate efficacy reduction from one vaccine to another. The Novavax data may indicate that the Pfizer and Moderna vaccines could also fall to 50% efficacy against some of these variants. Or the reduction could be much less...

        7 replies 35 retweets 314 likes
        Show this thread
      7. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        7)....What also needs to be kept in mind is that the numbers are still small. Once numbers are accumulating, the picture may change a little. And let's not forget, 50% would not be great, but its MUCH better than nothing......

        5 replies 31 retweets 377 likes
        Show this thread
      8. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        8)....especially if there is higher efficacy against severe disease. Let's wait for more data. And in the meantime, let's bring case numbers down.

        8 replies 25 retweets 368 likes
        Show this thread
      9. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        9) PS: Since I was called pedantic today already on Twitter. It is Shabir Madhi, not Shabir Maddi. @Novavax https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3 …

        7 replies 25 retweets 292 likes
        Show this thread
      10. Florian Krammer‏Verified account @florian_krammer 28 Jan 2021

        10) I take the comment about efficacy in HIV+ individuals back. Sloppy reading and misinterpretation of the data on my side. Thanks to the people who were making me aware. Apparently I am not pedantic enough.

        17 replies 14 retweets 400 likes
        Show this thread
      11. End of conversation
      1. New conversation
      2. Peter Suzman‏ @Biomaven 28 Jan 2021
        Replying to @florian_krammer

        What was not reassuring was the fact that the seropositive placebo group (seropositive was 30% of the trial) had an identical infection rate to the seronegative placebo group. So infection with original strain essentially provided no protection against B.1.351

        4 replies 5 retweets 50 likes
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