Fiora Esoterica

@fioraesoterica

's account for science, pharmacology, tech, etc.

Hyperfocus
Vrijeme pridruživanja: siječanj 2018.

Medijski sadržaj

  1. 14. pro 2019.

    you ever ask "huh, i wonder why it's called this" and then immediately regret it as the absolute worst english etymology slams you in the face

  2. 28. stu 2019.

    "An analysis of samples acquired four weeks after the German prohibition of JWH-018 took place found that the manufacturers had shortened the alkyl chain by one carbon to circumvent the ban" is an extremely cursed sentence

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  3. 14. stu 2019.

    just learned about efron's dice and my head hurts now

  4. 13. lis 2019.

    as usual, MCTB has an incredibly detailed and fantastic set of advice on what to do with "unwanted" emotions and thoughts. this is actually incredible so i'm just going to post the whole thing here.

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  5. 7. lis 2019.
    Odgovor korisniku/ci
  6. 7. lis 2019.

    on a related and interesting note, a thing i learned the other day is that there are some classes of drugs that are primarily metabolized by MAO in humans, rather than by P450, COMT, or other more familiar drug metabolism paths

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  7. 27. ruj 2019.

    shulgin also has some great radioactive drug "stories" (h/t )

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  8. 27. ruj 2019.

    and then!!! they confirmed that haematopoietic stem cells released from bone marrow are the actual progenitors of the fibrotic tissue, not proliferation in existing heart cells

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  9. 27. ruj 2019.

    this incredibly odd investigation discovered that, at least in mice, BONE MARROW 5-HT2B RECEPTORS appear to be required for cardiac valvulopathy to happen. what.

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  10. 26. ruj 2019.
    Odgovor korisniku/ci

    you may find this paper interesting, it's the best review i've found so far on the mechanisms of neurotoxicity

  11. 26. ruj 2019.

    new hobby: reading comments on papers instead of the papers themselves just to see the extremely dry snark

  12. 23. ruj 2019.
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  13. 23. ruj 2019.

    found this interesting old-looking patient medical history form at my dentist’s that has “taken fen-phen” on it

  14. 20. ruj 2019.

    hey, can any pharm-chem people explain to me how activation efficacy works? i had assumed it was a measure of agonism (e.g. 100 = full agonist), but 25I-NBOME is (iirc) a 5-HT2A full agonist, so this doesn't make sense.

  15. 18. ruj 2019.

    seeing pharmacology papers citing Erowid gives me life

  16. 18. ruj 2019.

    TIL: norfenfluramine was actually a super-agonist for 5-HT2B. Jesus Christ

  17. 18. ruj 2019.
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  18. 15. ruj 2019.
  19. 12. ruj 2019.
  20. 12. ruj 2019.

    by the way, speaking of neurotoxicity, there's some interesting hypotheses that a lot of studies tend to overestimate neurotoxicity because of the way their PET tracers work, as well as the more general problem of many studies not giving enough time to let receptors upregulate

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