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findingpneumo's profile
Keith Klugman
Keith Klugman
Keith Klugman
@findingpneumo

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Keith Klugman

@findingpneumo

Director of Pneumonia @Gatesfoundation Views are my personal views, not those of GF

Joined June 2014

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    Keith Klugman‏ @findingpneumo 17 Dec 2020

    First doses of Pfizer/Moderna vaccines are 90%+ effective after 14 days. Most high risk lives will be saved by giving all these limited early supplies of vaccine as first doses - second doses can be given later if first dose effectiveness wanes or when supply improves

    5:03 AM - 17 Dec 2020
    • 221 Retweets
    • 1,109 Likes
    • Will Mcloughlin 💁‍♂️🇦🇪🌐 Trusted Source Fiona Conlon David Zuser mild Zachary Wefel Michael Saji the moose in Saskatoon Gavin C
    38 replies 221 retweets 1,109 likes
      1. Stoic Mason  🥋 🔥‏ @MasonRMcClellan 20 Dec 2020
        Replying to @findingpneumo @michaelmina_lab

        I agree!

        0 replies 0 retweets 1 like
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      1. Snoubal ad astra‏ @QRancio 20 Dec 2020
        Replying to @findingpneumo @michaelmina_lab

        For 100% of everybody... What a success (irony)

        0 replies 0 retweets 0 likes
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      1. New conversation
      2. Ayush Chopra‏ @ayushchopra96 20 Dec 2020
        Replying to @findingpneumo @michaelmina_lab

        Agreed. However, https://www.webmd.com/vaccines/covid-19-vaccine/news/20201217/covid-19-vaccine-faq-safety-side-effects-efficacy … cites the 1 dose efficacy as 52%. How should that be interpreted? PS: I have no clinical background, just try to learn a bit about the vaccine.

        3 replies 0 retweets 17 likes
      3. Michael Mina‏Verified account @michaelmina_lab 20 Dec 2020
        Replying to @ayushchopra96 @findingpneumo

        It’s not accurate. It includes the first 14 days when there is almost no effect bc the vaccine has not started to work yet. Must censor out first ~2 weeks when assessing vaccine effect here. To not do so gives a very poor interpretation - one that greatly favors 2 dose regimen.

        6 replies 3 retweets 126 likes
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      2. Benur21‏ @Benur211 20 Dec 2020
        Replying to @Aintropy @findingpneumo

        People could just refuse the 2nd dose

        1 reply 0 retweets 3 likes
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      1. endure‏ @100Concerned 20 Dec 2020
        Replying to @findingpneumo @jjmplsmn

        second dose due in 28 days it is stated to be 94.5% effictive

        0 replies 0 retweets 0 likes
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      2. Adam Berliner, DO‏ @aberliner 20 Dec 2020
        Replying to @findingpneumo

        This would obviously need to be studied first as we cannot roll out a vaccine program that differs greatly from the manner in which it was studied.

        3 replies 0 retweets 17 likes
      3. Scott Leibrand‏ @scottleibrand 20 Dec 2020
        Replying to @aberliner @findingpneumo

        You may be correct that we “cannot” convince risk-averse regulators and policy-makers to allow it without more study. But “should not” is a much harder case to make.

        1 reply 0 retweets 23 likes
      4. Show replies
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      2. Nik Kolb‏ @nik_kolb 20 Dec 2020
        Replying to @findingpneumo

        How do we know if and when it would wane? People with 1 dose would need to be followed up rigorously (in another Phase III trial)

        2 replies 0 retweets 4 likes
      3. CADoctorJ‏ @CADoctorJ1 20 Dec 2020
        Replying to @nik_kolb @findingpneumo

        Only speculation at this point about any length of immunity length for one OR two dose regimen beyond a few months. Reassuaringly, CD4 and CD8 (like these mRNA vaccines ellicit) responses to SARS (also coronavirus family) lasted 6-10 years.

        0 replies 1 retweet 7 likes
      4. End of conversation

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