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Ewan Birney Retweeted
With help from
#deeplearning models,@PfamDB has expanded by almost 10% exceeding all expansion made to the database over the last decade
@Alexbateman1 discusses this work and what the future holds for protein family classification. https://www.ebi.ac.uk/about/news/perspectives/deep-learning-models-help-predict-protein-function/ …pic.twitter.com/d6En07Hfvp
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Ewan Birney Retweeted
Are you studying a species with a
#genome sequenced by@darwintreelife?

Find out how to explore and cross-reference newly annotated species in the #Ensembl rapid release website in next week's webinar.#genomics#bioinformatics#Ensembltraininghttps://twitter.com/EBItraining/status/1498946210563977217 …
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Ewan Birney Retweeted
Happy
#InternationalWomensDay! Don’t forget to tune into our panel discussion about bias in science and how to address it.
Today, 12:30 CET. Register below
https://www.embl.org/about/info/equality-diversity/events/breaking-biases-and-envisioning-inclusion-a-roundtable-discussion-for-international-womens-day-2022/ …
#IWD
#IWD2022
#BreakTheBias#Womenpic.twitter.com/xwb6lzQr8Q
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Looking ahead, just having longtidundinal imaging in the context of genetics (with or without COVID) will be super powerful for understanding aging and co-morbidities anyway.
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Wonderful work from the excellent
@uk_biobank crew to (a) have the foresight of a large well phenotyped cohort running and (b) add on specific reimaging for COVID. Hats off in particular to@fmrib_steve who is king of UK BioBank brain fMRI ....Show this threadThanks. Twitter will use this info to make your timeline better. UndoUndo -
Another great piece of COVID research from the UK research set up from the ever powerful
@uk_biobank, in this case looking at longintudinal changes to brain function due to COVID infectionhttps://www.nature.com/articles/s41586-022-04569-5 …Show this threadThanks. Twitter will use this info to make your timeline better. UndoUndo -
Ewan Birney Retweeted
Eleven blood markers, including the ABO protein that determines blood group, were implicated in severe COVID outcomes in a genomic analysis of clinical data https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010042 …
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Ewan Birney Retweeted
Out at 4pm today: our latest paper from GenOMICC reveals 16 new, robust genetic associations with critical Covid-19, some of which might lead directly to effective new treatments, just like our study in 2020 did. 1/nhttps://www.nature.com/articles/s41586-022-04576-6 …
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Ewan Birney RetweetedThanks. Twitter will use this info to make your timeline better. UndoUndo
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Ewan Birney Retweeted
FinnGen: Unique genetic insights from combining isolated population and national health register data https://medrxiv.org/cgi/content/short/2022.03.03.22271360v1 …
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I am... ok with my name being occassionally mangled, but when it keeps happening I do get a bit miffed </grumble>.
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The programmer in me would like there to be a flexible structure which both captures original names faithful to the culture+language (unicode for accents etc) and then there is some way to have this work in publications and email cleanly. Presumably not going to happen.
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I am totally aware that many non-English names (many Gaelic ones in Ireland) and letters (eg, ö in German or ø Danish/Norwegian, č in Croatian) and then conventions (Maternal name in Spanish, the Greek long/short forms) get totally mangled into English.
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For chinese colleagues, the pronunciation I believe is close to Yuan (in some dialects?), but obviously... I am not chinese and I think (depending on tone) Yuan might mean money or a usually female name. It's great my name has some analogs in Chinese, but I am not named for them.
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And it is not "Ewin" either which I am not sure how people get to. (is Ewin a name somewhere?). But they do.
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For french colleagues, it is not the same name as Erwan, and I am not misspelling my name in emails, missing out an r :). For American colleagues, it is not the same name as Evan - the "w" is correct not a mistyped v. Erwan and Evan are great names; just not mine.
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(There is a whole family of names here - Iuan, Ewan, Euan, Ewan, Eoughn, all linked to west-britain's Celtic cultures, and these are linked to Anglo-saxon John - think the Spanish Juan - indeed, I am legally John, and "Ewan" is my family nickname from my grandfather)
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<grumble>. a note on my first name "Ewan". It is pronounced phonetically "U-an" (though with a softer "U" sound than straight U) and it is a perfectly normal name in Britain, in this case more scottish (think... Ewan McGregor) vs the more Welsh "Ewen".
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Ewan Birney Retweeted
Also, anticipating rare variant analyses, diversity in levels of autozygosity is important to capture both dominant and recessive effects. Current large cohorts are biased to low autozygosity, under-ascertaining recessive effects.
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An allele on the receptor makes nicotine more addictive; it is harder to stop smoking therefore; this allele therefore increases lung cancer risk but *only* in an environment - a social environment - where many people at least start smoking.
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