See what’s really going on inside your nerves’ ends - real-time analysis of protein mobility at the #synapse courtesy of Rizzoli lab
embopress.org/doi/10.15252/e
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Rapid publication of research in molecular, cell & organismal biology.
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emboj.embopress.orgJoined December 2013
The EMBO Journal’s Tweets
Should you worry about not finishing revision experiments in time because of the current #COIVD19 crisis – we don’t. Just contact us to discuss the situation & possible extension. We’ll extend scooping protection to the time needed!
Congratulations to Tasuku Honjo and his team on the #NobelPrize in physiology or medicine for opening up #immunotherapy. Here, the first paper on PD-1 - already characterized as immunoglobulin superfamily, but years before immunoregulatory role emerged.
New measurements of inner #mitochondrial #membrane potential at resolution of individual #cristae reveals unexpected heterogeneity within single #mitochondria - find and coworkers
embopress.org/doi/10.15252/e
Once we received your manuscript , we know your work was done before that competing paper came out just now - applies also when transferring further to other journals or when you’ve posted recent #preprint on
embopress.org/policies
Reproducible image handling and analysis – commentary by #BioImageAnalysis experts & outlines importance of systematic processing description for proper interpretation of #microscopy data
embopress.org/doi/full/10.15
ISSUE 15
Review: How RNA Pol II speed shapes transcriptomes
N&V: vacuolar cargo selection by ZZ domains
Cover: et al
and: dendritic cell quorum sensing, post-synaptic eat-me signal, SMC5/6 substrate selection…
embopress.org/toc/14602075/2
Issue 12 features
Big TRAPP structures picture
chromatin safeguards ESC identity
review on tissue-scale mechanics & fate
Telomere elongation by POT1 cancer variants
Paraspeckles as block copolymer micelles
Cover: Bornstein, Meltzer,
embopress.org/toc/14602075/2
Is there an interconnection between #mitophagy and #pexophagy?
find that turnover of both #mitochondria and #peroxisomes depends on #autophagy receptor NIX/BNIP3L
embopress.org/doi/10.15252/e
Acin-Perez, Stiles, and colleagues describe a new method for measuring #mitochondrial #respiration in frozen biological and clinical samples
embopress.org/doi/10.15252/e
Issue 16 features circRNA review, highlighted work on phase separation in DNA repair & organellar proteasomes in antigen presentation, senataxin roles in transcription termination, & cancer cell secretion of collagen linearizer. Cover by lab
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ISSUE 14:
Reciprocal RTK priming on endosomes
Neuronal Miro1 and mitophagy
Spliceosome mutation in human mosaic aneuploidy
Redox homeostasis in Mycobacterium tuberculosis in host cells
Review on apoptosis inhibition treatment
Cover by Duerr et al
embopress.org/toc/14602075/2
New Issue 19:
Autophagy in human disease Review
Proteostasis reporter mice Resource
Tubulin acetylation & lysosomal acidification
TRIM46 degrading HDAC1 in breast cancer
Cover by Güttler, Aksu, Dobbelstein, Görlich et al &
embopress.org/toc/14602075/2
Final 2019 issue: Mitochondria fixing their own mistakes, a niche for aged muscle stem cells, LIN28A and Parkinson’s disease, pH changes in plant pathogen response, mechanisms of repeat-mediated DNA deletion...
Cover by Takii, Nakai et al
embopress.org/toc/14602075/2
#TGF beta signaling stimulates #glutamine #metabolism for proline biosynthesis, a process that buffers excessive #mitochondrial ROS generation - new work by Craig Thompson lab @sloan_kettering
embopress.org/doi/10.15252/e
New issue! Read on exercise-induced metabolites stimulating muscle hypertrophy, deposition of H2A.Z in plants & of CENP-A in flies, & chromatin players at uncapped telomeres & in endothelial inflammatory response. Recombinase monkeys by et al
embopress.org/toc/14602075/2
40 years ago, we published our very first issue!
We reflect on these origins and look ahead in our Editorial in this first issue of 2022
embopress.org/toc/14602075/2
Inner #mitochondrial membrane protein #prohibitin #PHB1 regulates #mtDNA release and downstream #inflammatory innate immune responses
embopress.org/doi/10.15252/e
New review by Koji Okamoto and colleagues gives an update on selective #autophagy of #mitochondria across species, and how #mitophagy pathways cooperate in normal or disease physiology
embopress.org/doi/10.15252/e
New EMBO J resource paper: Glyoxal as an alternative fixative to formaldehyde in immunostaining and super‐resolution microscopy emboj.embopress.org/content/early/
Confused about terminology? See our new review on Molecular definitions of autophagy and related processes emboj.embopress.org/content/early/
Issue #3 of our anniversary year:
Bacterial phage tolerance response
Unusual biogenesis of secretory IgM
N-RNA rings and glycoproteins in RSV virion structure
Cover by Soung-Hun Roh & Stephan Wilkens groups
embopress.org/toc/14602075/2
Latest issue! Read about microglia subtypes, yeast models of plant hormone signaling, nitric oxide roles in endothelial redox homeostasis, lncRNA-elicited DNA looping, and converging bacterial nucleotide signaling pathways. Cover by Lepko, Ninkovic et al
embopress.org/toc/14602075/2
#11February marks #InternationalDayofWomenandGirlsinScience - watch out for our series of female lead and/or corresponding authors whose work featured on recent covers of
#WomenInSTEM #WomenInScience
Cover issue 23 by John Rouse et al
Featured: neurotransmitters shaping cortical interneuron migration
Protein crowding in the inner mitochondrial membrane
Human replisome structure
HDAC limiting divergent non-coding transcription
embopress.org/toc/14602075/2
Issue 18:
Reviews on Cancer Evolution, EMT Roles in Tumor Progression
plus: Piwi/piRNA affect chromatin, DNA-protein crosslink repair via SUMO, dynamic adaptation in Notch signaling, DNA methylation in adult neurogenesis…
cover by Todd Schoborg
embopress.org/toc/14602075/2
Two oldies but goodies for your weekend read: Tips and tricks for statistics and data presentation from emboj.embopress.org/content/34/22/ emboj.embopress.org/content/35/16/
We are saddened and shocked to learn of the sudden passing of John Tooze, long-term Executive Secretary and forever remembered as the founding editor of , which he edited from 1982-2003
Cellular state switches and #reprogramming require proteome adjustments - & find this to require #autophagy in #Arabidopsis plant somatic cells
embopress.org/doi/10.15252/e
Issue 20 features FOXA2 control of pancreatic cancer cells, cyclin F cell-cycle control via E2Fs, a new convention-defying p53 mutant, & review on embryonic organization by tissue rheology. Cover image by & , Hoogenraad et al
embopress.org/toc/14602075/2
Cell-free in vitro reconstitution by Shohei Yamamoto et al shows that #actin network architecture can ensure robust centering or sensitive decentering of #microtubule-organizing center #MTOC #centrosome
embopress.org/doi/10.15252/e
Issue 22:
Inflammation caused by DNA hypomethylation
Evolution of microtubule drug resistance
Featured:
Material transfer by photoreceptor nanotubes, lipid metabolism control by PKM2-TMEM33
Resource:
PET imaging deep neuronal circuits
Cover by
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Issue 15 features ERAD doppelgänger EGAD, ERp18 activation of ATF6 in UPR, proteomics markers of melanoma MAPKi resistance, events at ER-mitochondria interfaces, bacterial replication origin unwinding, & review on cancer models. Cover by
embopress.org/toc/14602075/2
What #actin probe suits best for studying cellular actin filaments? #CryoEM work by Minhajuddin Sirajuddin Kutti Vinothkumar et al reveals different principles of actin recognition by #phalloidin, #utrophin and #LifeAct
embopress.org/doi/10.15252/e
Final issue of EJ volume 40!
Features on viral super cell fusers and SNX10-mediated LPS sensing
Plus: bacterial dual-function RNA, UBR7 as histone chaperone, asparagine and adipose thermogenesis
et al cover illustration by
embopress.org/toc/14602075/2
Synergy between #lipiddroplet biogenesis and #mitophagy sustains cell and tissue integrity upon iron depletion
and co-workers
embopress.org/doi/10.15252/e
Issue 20:
Catching BAK in action at membranes (incl. N&V)
Subcellular localization of nucleolin
CTCF modulation of UV DNA damage
Neuropeptide-driven circadian neuronal network
...
Cover: Wang, Shao and colleagues
embopress.org/toc/14602075/2
#PERK signaling promotes #mitochondrial elongation by remodeling membrane #phosphatidic acid
embopress.org/doi/full/10.15
#Auxin-dependent regulation of cell division rates governs #Arabidopsis root #thermomorphogenesis
Marcel Quint et al show a direct temperature-sensing mechanism acts on cell proliferation in the apical #meristem to control root growth
embopress.org/doi/10.15252/e
In the latest issue: Tissue macrophage identity guardians, ATRX roles in ALT telomere maintenance, lymph vessels in a hairy niche, TRAPP stress granules arresting secretion, & cellular plasticity commentary. Cover by Kortzak, Machtens, Fahlke et al
embopress.org/toc/14602075/2
EMBO J commentary on key concepts in statistical analysis and best practices in study design emboj.embopress.org/content/early/
Cancer Evolution: Darwin and Beyond – @_Y_N0T discuss evolutionary concepts underlying cancer progression and selective pressure on tumors
embopress.org/doi/10.15252/e
What happens to human cells at very cold temperatures, as during surgery? Andre Furger and colleagues find #chromatin compaction and nuclear retention of clock mRNAs, whose release upon rewarming reset the cellular #circadian clock
embopress.org/doi/10.15252/e
TOR acts as a metabolic gatekeeper for auxin-dependent lateral root initiation in Arabidopsis thaliana
and coworkers
embopress.org/doi/10.15252/e
Autophagy in major human diseases – et al. bring together broad perspectives on the contribution of #autophagy to multiple pathological phenotypes, and discuss the therapeutic potential of autophagy modulation
embopress.org/doi/10.15252/e
Issue 6: Resources on ncRNA & ovarian cancer organoids; transcription rewires chromatin/lamina interactions, precursor miRNAs hitchhike on endosomes, & excessive proofreading at replication hurdles. Cover by Marlieke Jongsma et al
embopress.org/toc/14602075/2
CMV #herpesvirus subverts innate immunity via specific antagonist m152 of antiviral STING functions, sparing STING activation of NF‐κB & exploiting it for viral replication, find
—> emboj.embopress.org/content/early/
—> bit.ly/2HDUaUc
New issue with… neurological chimera commentary, cGAS in DNA repair, ribosome capture by viral IRES, RNF8 regulation by p97/ATX3, and inflammasome instruction by adaptive immunity
Noncanonical #phosphorylation cover by for et al
embopress.org/toc/14602075/2
Protein complex assembly #qualitycontrol in action:
#cryoEM by shows how #CRL4-#DCAF12 E3 #ligase engages C-terminal di-Glu #degron in CCT5 recognizable only when this subunit is not incorporated into the #TRiC/#CCT #chaperone complex
embopress.org/doi/10.15252/e
How do #viruses exploit host cell #lipiddroplets for their replication?
Binbin Ding and coworkers show #SARSCoV2 ORF6 protein to bring lipid droplets in contact with ER and #mitochondria to alter cellular #lipid flux
embopress.org/doi/10.15252/e
Issue 3: Spotlights on torpedos terminating transcription & nuclear stress bodies aiding intron retention; respiratory supercomplexes, ribosome stalling, all-inclusive adipocyte vesicles & 2x biomechanical events in tissue replacement
Cover:
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Clara Sánchez-Rodríguez et al use genetically encoded sensors for absolute pH changes across plant plasma membranes in response to biotic stress, reveal direct connections between apoplast acidification, pathogen defense, and plant growth:
embopress.org/doi/10.15252/e
New issue! Read on LRRK2 in ER/mitochondrial tethering, pluripotent state interconversion by Zfp281, centromeric determinants of chromosome-specific aneuploidy, & how plant phosphate status governs host microbial preferences. Cover by Schäfer, Schuck et al
embopress.org/toc/14602075/2
Termination of STING responses is mediated via #ESCRT- and #ubiquitin-dependent degradation to prevent unwarranted #inflammation
Katherine Balka et al
embopress.org/doi/10.15252/e
Stress-induced #mitochondria-derived #vesicles are routed towards degradation in #lysosomes by #Tollip adaptor and #Parkin ubiquitin ligase – find and coworkers
embopress.org/doi/10.15252/e
Issue 17: Editorial to our Cancer Series & Review on tumor cell competition
Cover by et al
Plus: adaptive tolerance against autoimmune reactions, tubulin glutamylation in axonal transport, Tudor staphylococcal nuclease & stress granule
embopress.org/toc/14602075/2
#Ribosome profiling and #cryoEM reveals how inhibitory #codon pairs and poly(A) tracts stall translation with decoding-incompatible mRNA conformations in the ribosomal decoding center
-> Study by , Laura Lessen et al
embopress.org/doi/10.15252/e
Insights into the mysterious conjugation of #ubiquitin-fold modifier #UFM1:
et al identify heterodimeric UFL1/UFBP1 as non-canonical scaffold-type E3 #ligase and #CDK5RAP3 as adaptor for #ribosome mono-#UFMylation
embopress.org/doi/10.15252/e
Inhibition of ATP synthase reverse activity in #mitochondrial pathologies can restore energy homeostasis, and improve muscle strength in Duchenne Muscular Dystrophy models
et al
embopress.org/doi/10.15252/e
Adjusting protein turnover rates to bioenergetic demand:
identify TMBIM5 as a calcium/proton exchanger and inhibitor of m-AAA protease in the #mitochondrial inner membrane
embopress.org/doi/10.15252/e
Issue #2 with cover & feature on Rosselot, Moore, Hong et al
Review by on tumor states at single-cell resolution
Plus: Amyloid assembly via heterotypic beta interactions; tBID as BAX-like apoptosis effector
embopress.org/toc/14602075/2
Phase separation of Hippo signalling complexes
shows that mechanical strain and growth factor signaling regulate the condensation of Hippo pathway components in Drosophila and mammalian epithelia
embopress.org/doi/10.15252/e
Issue 8 features #geranylgeranyl Golgi donations, transmission of pathogenic #C9orf72 in ALS/FTD, light-responsive #miRNA clearing retinal cells, and #Chlamydia rewiring host cell metabolism. cover for Pei, Zheng and coworkers
embopress.org/toc/14602075/2
New twist to nutrient-controlled #mTORC1 #lysosome recruitment and activation: finds membrane curvature sensor #ArfGAP1 to suppress it under amino acids starvation independent of GAP activity
embopress.org/doi/10.15252/e
Insights into transcriptional contribution to #pancreatic cancer development: et al find #epithelial program driven by HNF1A and KDM6A suppressing Kras-G12D-driven tumorigenesis
embopress.org/doi/10.15252/e
How do nutrient-starved cells preserve a basal supply of dormant ribosomes?
Michael Hall and colleagues identify conserved TORC1 phosphorylation and inhibition of ribosome-binding factor Stm1/SERBP1 in yeast and human cells
embopress.org/doi/10.15252/e
A network of small RNAs regulates sporulation initiation in Clostridioides difficile
& colleagues
Small RNA/target interaction maps reveal first RNA chaperone Hfq-dependent RNA interactome in a gram-positive pathogen
embopress.org/doi/10.15252/e
TFEB-dependent lysosome biogenesis is required for senescence
Bernadette Carroll and coworkers
embopress.org/doi/10.15252/e
Seminal #ubiquitin paper from #40yearsEMBOJ:
Cecile Pickart and colleagues defined tetra-ubiquitin chains as minimum requirement for proteasomal recognition
doi.org/10.1093/emboj/
embopress.org/page/journal/1
Dewson and colleagues show that #autophagy clearance of damaged #mitochondria and suppression of #apoptosis effector proteins are coordinated functions of the Parkin ubiquitin ligase that are lost in #Parkinsonsdisease
emboj.embopress.org/content/early/
Single-cell HiC data show that cohesin-dependent loop extrusion drives the spatial organization of mammalian genomes emboj.embopress.org/content/early/
emboj.embopress.org/content/early/
Our new issue with insights on peroxide-induced cell death, antiviral immune signaling, single-cell transcriptomics of human retina, and more! Featuring review on DNA damage checkpoint signaling at 30 and cover by et al
embopress.org/toc/14602075/2
A link between dysfunctional #mitochondrial translation and #lysosomal function - via HIF1a-regulated NAD+ production supporting local glycolytic ATP generation around lysosomes – find Takeshi Uchiumi and coworkers
embopress.org/doi/10.15252/e
Issue 8:
Focus review on RNA-mediated heterochromatin formation
Common adaptations to distinct chromosomal instabilities
cGAS/STING activating immunoproteasomes
Epigenetic reprogramming in plant shade responses
cover for
embopress.org/toc/14602075/2
How does #centrosome amplification -common in cancer- promote cell migration through confined spaces?
et al show that it alters intracellular organization via effects on tubulin acetylation and organelle transport along microtubules
embopress.org/doi/full/10.15
#Redox-sensitive oligomerization of specific cysteine residues makes #autophagy receptor #NDP52 a sensor of ROS from damaged #mitochondria, which initiates #PINK1/#Parkin-mediated #mitophagy
and collaborators
embopress.org/doi/10.15252/e
How are specific dysfunctional #mitochondria removed under steady-state conditions?
Yi Cui et al show SCF-#FBXL4 ubiquitin ligase, mutated in MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3
embopress.org/doi/10.15252/e
Creativity as antidote to research becoming too predictable
In this commentary, Markus Baer & Katrine Sonne-Hansen argue why risk-taking & blue-sky research should be actively fostered in budding scientists
Cf.
embopress.org/doi/10.15252/e
Exposed phosphatidylserine on pre- and postsynaptic membranes functions as an ‘eat-me’ signal that mediates developmental synaptic pruning by microglia - and coworkers
embopress.org/doi/10.15252/e
The key #mitotic kinase #CyclinB1/#CDK1 has a surprising structural role at the #kinetochore – as scaffold for the spindle assembly #checkpoint that keeps its own degradation in check! Surprising findings by and coworkers
embopress.org/doi/10.15252/e
Best‐practice summary and hands‐on guide on how to most usefully display your data emboj.embopress.org/content/early/
Featured in Issue 11: Microbiota dysbiosis in tumorigenesis, CDK1 control by USP7
Hair follicle stem cell Review
Single-cell breast tissue expression Resource
And: activation of Plasmodium egress protease - and more!
Cover by
embopress.org/toc/14602075/2
How do mitochondria obtain the ribonucleotides needed for organellar transcription?
et al show key fueling role of #mitochondrial #nucleoside diphosphate kinase #NME6 that phosphorylates #pyrimidine nucleosides
embopress.org/doi/full/10.15
Get up-to-date on #RNA m6A #methylation: & Chuan He review #posttranscriptional gene regulation roles of the predominant mRNA modification, mechanisms of its deposition/removal, and the potential of its therapeutic targeting
embopress.org/doi/10.15252/e
How to protect cells from excess accumulation of mitochondrial precursor proteins in the cytosol?
et al identify #MitoStores - cytoplasmic storage granules serving as buffers in yeast cells upon overwhelmed #mitochondrial import
embopress.org/doi/10.15252/e
A CRISPR-Cas9-tagging approach to induce chromosome-specific segmental aneuploidies: assembling ectopic kinetochores at endogenous repeats recapitulates disease-linked missegregation in human cells
Sara Johnson et al
embopress.org/doi/10.15252/e
Unexpected #autophagy roles in signaling:
Neuron-specific #ATG5 deletion reveals its importance for regulating cAMP/PKA-dependent phosphorylation of #postsynaptic density proteins
and collaborators
embopress.org/doi/10.15252/e
Blue native PAGE‐based “IGX‐MS” method by et al allows selective analysis of co‐occurring protein complexes – complementary approach to in‐solution #crosslinking mass spectrometry useful for structural modeling
embopress.org/doi/full/10.15
Sensor NLR #immune proteins activate #oligomerization of their NRC helpers in response to #plantpathogens
embopress.org/doi/full/10.15
Interested in #autophagy? Visit the latest article collection related to this fascinating topic!
As everything this year, virtual – at embopress.org/page/journal/1
“Mitochondrial Safeguard”: Hiromi Sesaki et al define a stress response that protects from hyperconnectivity of #mitochondria via flickering-induced Oma1 Activation
embopress.org/doi/10.15252/e
Is #mitochondrial dysfunction in muscle cause or consequence of #metabolic disorders? proves that muscle #OXPHOS inhibition affects whole-body lipid metabolism and insulin sensitivity in mice
embopress.org/doi/10.15252/e
Activated #neutrophils can induce #ROS-dependent #telomere dysfunction and #paracrine #senescence in neighboring cells - find Anthony Lagnado et al
embopress.org/doi/10.15252/e
What determines whether a plant tolerates or avoids the shade of others?
Jaime Martinez-Garcia and coworkers compare Arabidopsis with C. hirsuta and find role of an HFR1-PIF7 module making the difference
embopress.org/doi/10.15252/e
Extensive multivalent interactions between #BRCA1/#BARD1 E3 ligase IDRs & #nucleosome substrates facilitate chromatin recruitment & contribute to histone H2A ubiquitylation and to DNA repair
et al
embopress.org/doi/10.15252/e
Spike protein mutations expressed by emerging #SARSCoV2 variants differentially affect #ACE2 receptor binding & antibody escape, and enhance #syncytia formation of host cells
et al
embopress.org/doi/10.15252/e
#USP7 inhibitors trigger untimely #CDK1 activation throughout #cellcycle via #PP2A & cause #DNAdamage in replicating cells - new mechanism underlying their toxicity
and coworkers
embopress.org/doi/10.15252/e
More insight into #Urm1 as evolutionary bridge between #ubiquitin-like protein conjugation and thiolation: E2/E3-independent target protein leads to cysteine #persulfidation
et al
embopress.org/doi/10.15252/e
Happy EMBO Journal editors celebrating our 5000th follower on Twitter! Thanks so much the attention, we hope you like our content ;-)
Is there a role for #phospholipids other than PI3P and PE in #autophagosome biogenesis?
Zevi Elazar and coworkers find the #phosphatidylcholine-to-#phosphatidylserine ratio to control closure of #phagophore membranes
embopress.org/doi/10.15252/e
